Literature summary for 1.1.1.21 extracted from

Hao, X.; Han, Z.; Li, Y.; Li, C.; Wang, X.; Zhang, X.; Yang, Q.; Ma, B.; Zhu, C.
Synthesis and structure-activity relationship studies of phenolic hydroxyl derivatives based on quinoxalinone as aldose reductase inhibitors with antioxidant activity (2017), Bioorg. Med. Chem. Lett., 27, 887-892 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
epalrestat	-	Homo sapiens
additional information	phenolic hydroxyl groups are important both in C3 side chain and the core structure of quinoxalinone cores for constructing potent ALR2 inhibitors with antioxidant activity	Homo sapiens
[3-(2,4-dihydroxyphenyl)-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens
[3-(2,5-dihydroxyphenyl)-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens
[3-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens
[3-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid	most potent activity	Homo sapiens
[3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens
[3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens
[3-[(E)-2-(4-hydroxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens
[3-[(E)-2-(4-hydroxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid	most active inhibitor evaluated	Homo sapiens
[3-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens
[3-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens
[3-[2-(4-hydroxyphenyl)ethyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens
[6-methoxy-2-oxo-3-(2,4,6-trihydroxyphenyl)quinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens
[7-methoxy-2-oxo-3-(2,4,6-trihydroxyphenyl)quinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens
[7-methoxy-2-oxo-3-[(E)-2-phenylethenyl]quinoxalin-1(2H)-yl]acetic acid	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15121	-	-

Synonyms

Synonyms	Comment	Organism
AKR1B1	-	Homo sapiens
ALR2	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00006	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[3-[(E)-2-(4-hydroxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid
0.00009	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	epalrestat
0.0001	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[3-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid
0.0001	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[3-[(E)-2-(4-hydroxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid
0.00016	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[3-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid
0.00017	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[7-methoxy-2-oxo-3-(2,4,6-trihydroxyphenyl)quinoxalin-1(2H)-yl]acetic acid
0.00018	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[3-(2,4-dihydroxyphenyl)-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid
0.00019	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid
0.00021	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[3-[(E)-2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid
0.00027	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[6-methoxy-2-oxo-3-(2,4,6-trihydroxyphenyl)quinoxalin-1(2H)-yl]acetic acid
0.00051	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[3-[2-(4-hydroxyphenyl)ethyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid
0.00085	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[3-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid
0.00087	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[3-(2,5-dihydroxyphenyl)-7-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid
0.00092	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[7-methoxy-2-oxo-3-[(E)-2-phenylethenyl]quinoxalin-1(2H)-yl]acetic acid
0.00098	-	pH not specified in the publication, temperature not specified in the publication	Homo sapiens	[3-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-6-methoxy-2-oxoquinoxalin-1(2H)-yl]acetic acid

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Release 2023.1 (January 2023)