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Literature summary for 1.1.1.21 extracted from

  • Lee, I.S.; Kim, Y.J.; Jung, S.H.; Kim, J.H.; Kim, J.S.
    Flavonoids from Litsea japonica inhibit AGEs formation and rat lense aldose reductase in vitro and vessel dilation in zebrafish (2016), Planta Med., 83, 318-325.
    View publication on PubMed
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
epicatechin
-
 Rattus norvegicus
kaempferol
-
 Rattus norvegicus
kaempferol 3-O-rutinoside
-
 Rattus norvegicus
additional information flavonoids from Litsea japonica inhibit advanced glycation end products formation and rat lense aldose reductase in vitro with IC50 values of 0.0074-0.072 mM, flavonoid structure determinations by NMR spectroscopy, overview. No significant inhibition by 1, 2, afzelin, quercitrin, rutin, and lyoniside Rattus norvegicus
Myricitrin
-
 Rattus norvegicus
quercetin 3-O-beta-D-apiofuranosyl-(1->2)-beta-D-glucopyranoside
-
 Rattus norvegicus
rhamnocitrin-3-O-rhamnoside
-
 Rattus norvegicus
tiliroside
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus P07943
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 IC50 values and 95% confidence intervals of flavonoids from Litsea japonica on advanced glycation end products formation, IC50 values of 0.0074-0.072 mM, overview Rattus norvegicus additional information

General Information

General Information Comment Organism
malfunction inhibition of the enzyme causes advanced glycation end products formation Rattus norvegicus