Inhibitors | Comment | Organism | Structure |
---|---|---|---|
epalrestat | - |
Rattus norvegicus | |
fidarestat | - |
Rattus norvegicus | |
additional information | inhibitor development, synthesis and molecular docking, overview | Rattus norvegicus | |
N-(2-phenylethyl)-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-(2-phenylethyl)-N-[(3-nitrophenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-(2-phenylethyl)-N-[(4-bromophenyl)sulfonyl]glycine | no inhibition of ALR1 | Rattus norvegicus | |
N-(2-phenylethyl)-N-[(4-chlorophenyl)sulfonyl]glycine | no inhibition of ALR1 | Rattus norvegicus | |
N-(2-phenylethyl)-N-[(4-fluorophenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-(2-phenylethyl)-N-[(4-methylphenyl)sulfonyl]glycine | no inhibition of ALR1 | Rattus norvegicus | |
N-(2-phenylethyl)-N-[(4-nitrophenyl)sulfonyl]glycine | no inhibition of ALR1 | Rattus norvegicus | |
N-(2-phenylethyl)-N-[(4-trifluoromethylphenyl)sulfonyl]glycine | no inhibition of ALR1 | Rattus norvegicus | |
N-benzyl-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-benzyl-N-[(2-naphthalenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-benzyl-N-[(3-nitrophenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-benzyl-N-[(4-bromophenyl)sulfonyl]glycine | no inhibition of ALR1 | Rattus norvegicus | |
N-benzyl-N-[(4-chlorophenyl)sulfonyl]glycine | no inhibition of ALR1 | Rattus norvegicus | |
N-benzyl-N-[(4-fluorophenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-benzyl-N-[(4-methylphenyl)sulfonyl]glycine | no inhibition of ALR1 | Rattus norvegicus | |
N-benzyl-N-[(4-nitrophenyl)sulfonyl]glycine | no inhibition of ALR1 | Rattus norvegicus | |
N-benzyl-N-[(4-trifluoromethylphenyl)sulfonyl]glycine | no inhibition of ALR1 | Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(1,10-biphenyl)-4-sulfonyl]glycine | - |
Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(1-naphthalenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(2-naphthalenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(4-bromophenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(4-chlorophenyl)sulfonyl]glycine | no inhibition of ALR1 | Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(4-fluorophenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(4-nitrophenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(4-trifluoromethylphenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(5-dimethylamino-1 naphthalenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
N-[2-(2-thienyl)ethyl]-N-[(5-dimethylamino-1-naphthalenyl)sulfonyl]glycine | - |
Rattus norvegicus | |
S12728 | inhibitor of ALR2, but no inhibition of ALR1 | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Sprague-Dawley | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glucuronate + NADPH | substrate of aldehyde reductase ALR1 | Rattus norvegicus | ? + NADP+ | - |
? | |
D-glucuronate + NADPH | substrate of aldehyde reductase ALR1 | Rattus norvegicus Sprague-Dawley | ? + NADP+ | - |
? | |
DL-glyceraldehyde + NADPH | substrate of aldose reductase ALR2 | Rattus norvegicus | glycerol + NADP+ | - |
? | |
DL-glyceraldehyde + NADPH | substrate of aldose reductase ALR2 | Rattus norvegicus Sprague-Dawley | glycerol + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
aldehyde reductase | - |
Rattus norvegicus |
aldose reductase | - |
Rattus norvegicus |
ALR1 | - |
Rattus norvegicus |
ALR2 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at, ALR2 | Rattus norvegicus |
37 | - |
assay at, ALR1 | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.2 | - |
assay at, ALR2 | Rattus norvegicus |
7.2 | - |
assay at, ALR1 | Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000431 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine | |
0.0011 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-(2-phenylethyl)-N-[(3-nitrophenyl)sulfonyl]glycine | |
0.0012 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(1,10-biphenyl)-4-sulfonyl]glycine | |
0.0022 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine | |
0.0036 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-(2-phenylethyl)-N-[(4-bromophenyl)sulfonyl]glycine | |
0.00427 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(2-naphthalenyl)sulfonyl]glycine | |
0.0046 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(4-bromophenyl)sulfonyl]glycine | |
0.0055 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-(2-phenylethyl)-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine | |
0.0055 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-benzyl-N-[(3-nitrophenyl)sulfonyl]glycine | |
0.0059 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(2-naphthalenyl)sulfonyl]glycine | |
0.0065 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-benzyl-N-[(2-naphthalenyl)sulfonyl]glycine | |
0.0076 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(3-nitrophenyl)sulfonyl]glycine | |
0.0083 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-benzyl-N-[(2-naphthalenyl)sulfonyl]glycine | |
0.0104 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-(2-phenylethyl)-N-[(3-nitrophenyl)sulfonyl]glycine | |
0.0108 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(4-fluorophenyl)sulfonyl]glycine | |
0.0119 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(4-nitrophenyl)sulfonyl]glycine | |
0.0124 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(1-naphthalenyl)sulfonyl]glycine | |
0.0133 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(5-dimethylamino-1 naphthalenyl)sulfonyl]glycine | |
0.0147 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(1-naphthalenyl)sulfonyl]glycine | |
0.016 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(5-dimethylamino-1-naphthalenyl)sulfonyl]glycine | |
0.017 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | epalrestat | |
0.0173 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-benzyl-N-[(4-nitrophenyl)sulfonyl]glycine | |
0.018 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-benzyl-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine | |
0.0188 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | S12728 | |
0.021 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-(2-phenylethyl)-N-[(4-nitrophenyl)sulfonyl]glycine | |
0.0224 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(4-chlorophenyl)sulfonyl]glycine | |
0.0234 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-benzyl-N-[(4-chlorophenyl)sulfonyl]glycine | |
0.0248 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-benzyl-N-[(4-methylphenyl)sulfonyl]glycine | |
0.0265 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(1,10-biphenyl)-4-sulfonyl]glycine | |
0.029 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-benzyl-N-[(4-fluorophenyl)sulfonyl]glycine | |
0.0339 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-benzyl-N-[(4-fluorophenyl)sulfonyl]glycine | |
0.0454 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-(2-phenylethyl)-N-[(4-chlorophenyl)sulfonyl]glycine | |
0.0471 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-(2-phenylethyl)-N-[(4-fluorophenyl)sulfonyl]glycine | |
0.0525 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(4-trifluoromethylphenyl)sulfonyl]glycine | |
0.0576 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine | |
0.0578 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(4-bromophenyl)sulfonyl]glycine | |
0.0612 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(4-fluorophenyl)sulfonyl]glycine | |
0.0659 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-(2-phenylethyl)-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine | |
0.0683 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-(2-phenylethyl)-N-[(4-trifluoromethylphenyl)sulfonyl]glycine | |
0.0704 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-benzyl-N-[(4-bromophenyl)sulfonyl]glycine | |
0.0732 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(4-trifluoromethylphenyl)sulfonyl]glycine | |
0.0745 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-(2-phenylethyl)-N-[(4-fluorophenyl)sulfonyl]glycine | |
0.0747 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-benzyl-N-[(4-trifluoromethylphenyl)sulfonyl]glycine | |
0.0804 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-benzyl-N-[(2-fluoro-4-bromophenyl)sulfonyl]glycine | |
0.0847 | - |
pH 6.2, 30°C, ALR2 | Rattus norvegicus | N-(2-phenylethyl)-N-[(4-methylphenyl)sulfonyl]glycine | |
0.0847 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-[2-(2-thienyl)ethyl]-N-[(4-nitrophenyl)sulfonyl]glycine | |
0.0881 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | N-benzyl-N-[(3-nitrophenyl)sulfonyl]glycine | |
0.094 | - |
pH 7.2, 37°C, ALR1 | Rattus norvegicus | epalrestat |