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Literature summary for 1.1.1.21 extracted from

  • Tammali, R.; Saxena, A.; Srivastava, S.K.; Ramana, K.V.
    Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle (2010), Endocrinology, 151, 2140-2150.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
sorbinil
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-hydroxy-trans-2-nonenal + NADPH + H+ Rattus norvegicus
-
 1,4-dihydroxynonane + NADP+
-
 ?
glutathione-4-hydroxy-trans-2-nonenal + NADPH + H+ Rattus norvegicus
-
 glutathione-1,4-dihydroxynonane + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Rattus norvegicus
-
vascular smooth muscle cell
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-hydroxy-trans-2-nonenal + NADPH + H+
-
 Rattus norvegicus 1,4-dihydroxynonane + NADP+
-
 ?
glutathione-4-hydroxy-trans-2-nonenal + NADPH + H+
-
 Rattus norvegicus glutathione-1,4-dihydroxynonane + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus

General Information

General Information Comment Organism
additional information inhibition of the enzyme prevents 4-hydroxy-trans-2-nonenal-and glutathione-4-hydroxy-trans-2-nonenal-induced E2F-1 expression Rattus norvegicus
physiological function aldose reductase is involved in the polyol pathway, and regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle. It prevents high glucose- or TNFalpha-induced vascular smooth muscle cell proliferation by accumulating the cells in the G1 phase Rattus norvegicus