Inhibitors | Comment | Organism | Structure |
---|---|---|---|
sorbinil | - |
Mus musculus | |
Tolrestat | - |
Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
apolipoprotein E-null mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
aorta | - |
Mus musculus | - |
blood vessel | - |
Mus musculus | - |
smooth muscle | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | aldose reductase metabolizes both free and phospholipid aldehydes and exacerbates atherosclerotic lesion formation, increase in lesion area attributable to inhibition of the enzyme or deletion of the gene encoding the enzyme occurs in both male and female mice, phenotype of enzyme-deficient male and female mice with increases in arterial lesions, macrophage accumulation and interstitial fibrosis, and decreases smooth muscle cell content of arterial lesions, detailed overview | Mus musculus |