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Literature summary for 1.1.1.21 extracted from

  • Baba, S.P.; Wetzelberger, K.; Hoetker, J.D.; Bhatnagar, A.
    Posttranslational glutathiolation of aldose reductase (AKR1B1): a possible mechanism of protein recovery from S-nitrosylation (2009), Chem. Biol. Interact., 178, 250-258.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
sorbinil
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
glutathionylation the activity of AKR1B1 is regulated by nitric oxide and the de-nitrosylation of AKR1B1 is mediated or facilitated by intracellular reductants such as glutathione and ascorbate Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DL-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
?

Synonyms

Synonyms Comment Organism
AKR1B1
-
Homo sapiens
aldose reductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens