Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid | uncompetitive with both D,L-glyceraldehyde and NADPH | Rattus norvegicus | |
(2-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid | uncompetitive with both D,L-glyceraldehyde and NADPH | Rattus norvegicus | |
zopolrestat | - |
Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.054 | - |
NADPH | isoform ALR2, pH 6.2, 30°C | Rattus norvegicus | |
0.585 | - |
DL-glyceraldehyde | isoform ALR2, pH 6.2, 30°C | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | isoform ALR1 | Rattus norvegicus | - |
lens | isoform ALR2 | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DL-glyceraldehyde + NADPH | - |
Rattus norvegicus | glycerol + NADP+ | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000005 | - |
zopolrestat | pH 6.2, 30°C, isoform ALR2 | Rattus norvegicus | |
0.0167 | - |
(2-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid | pH 6.2, 30°C, isoform ALR2 | Rattus norvegicus | |
0.0182 | - |
(2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid | pH 6.2, 30°C, isoform ALR2 | Rattus norvegicus | |
0.328 | - |
(2-phenethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid | pH 7.2, 37°C, isoform ALR1 | Rattus norvegicus | |
3.081 | - |
(2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid | pH 7.2, 37°C, isoform ALR1 | Rattus norvegicus |