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Literature summary for 1.1.1.21 extracted from

  • Alexiou, P.; Nicolaou, I.; Stefek, M.; Kristl, A.; Demopoulos, V.J.
    Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors (2008), Bioorg. Med. Chem., 16, 3926-3932.
    View publication on PubMed
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
4-amino-N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamide
-
 Rattus norvegicus
N-(3,5-difluoro-4-hydroxyphenyl)-4-methoxybenzenesulfonamide
-
 Rattus norvegicus
N-(3,5-difluoro-4-hydroxyphenyl)-4-nitrobenzenesulfonamide
-
 Rattus norvegicus
N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamide compound exhibits high antioxidant potential. Determination of intestine permeability Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
 Rattus norvegicus
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0141
-
 4-amino-N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamide
-
 Rattus norvegicus
0.0155
-
 N-(3,5-difluoro-4-hydroxyphenyl)-4-methoxybenzenesulfonamide
-
 Rattus norvegicus
0.0329
-
 N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamide
-
 Rattus norvegicus
0.0444
-
 N-(3,5-difluoro-4-hydroxyphenyl)-4-nitrobenzenesulfonamide
-
 Rattus norvegicus