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Literature summary for 1.1.1.21 extracted from

  • Kayser, M.M.; Drolet, M.; Stewart, J.D.
    Application of newly available bio-reducing agents to the synthesis of chiral hydroxy-beta-lactams: model for aldose reductase selectivity (2005), Tetrahedron Asymmetry, 16, 4004-4009.
No PubMed abstract available
Search for more literature for 1.1.1.21

Application

Application Comment Organism
drug development homochiral 3-hydroxy-4-substituted beta-lactams serve as precursors to the corresponding alpah-hydroxy-beta-amino acids, the enzyme might be useful insynthesis of these key components of many biologically and therapeutically important compounds Saccharomyces cerevisiae
synthesis homochiral 3-hydroxy-4-substituted beta-lactams serve as precursors to the corresponding alpah-hydroxy-beta-amino acids, the enzyme might be useful insynthesis of these key components of many biologically and therapeutically important compounds Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(3R,4S/3S,4R)-3,4-(cis)acetate-beta-lactam + NADPH + H+ screening of 19 individual yeast reductases for their effciency and enantioselectivity, overview Saccharomyces cerevisiae 4-hydroxyazetidine-2,3-diyl diacetate + NADP+ stereochemistry of products of the different enzymes, detailed overview ?

Subunits

Subunits Comment Organism
monomer
-
 Saccharomyces cerevisiae

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7 8 assay at Saccharomyces cerevisiae

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Saccharomyces cerevisiae