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Literature summary for 1.1.1.21 extracted from

  • Pau, A.; Asproni, B.; Murineddu, G.; Boatto, G.; Grella, G.E.; Rakowitz, D.; Costantino, L.; Pinna, G.A.
    Thienocinnolinone alkanoic acid derivatives as aldose reductase inhibitors (2006), Med. Chem., 2, 39-45.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
8-bromo-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid 4fold decreased inhibitory potency compared to the nonsubstituted parent compound Bos taurus
8-chloro-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid 4fold decreased inhibitory potency compared to the nonsubstituted parent compound Bos taurus
8-methyl-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid 2fold decreased inhibitory potency compared to the nonsubstituted parent compound Bos taurus
thienocinnolinone alkanoic acid derivatives i.e. 8-halogen-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid derivatives, synthesis and inhibitory potency, IC50 as low as 0.0314 mM, the length of the N2 alkanoic chain strongly influences the inhibitory activity, overview Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
Bos taurus
-

Synonyms

Synonyms Comment Organism
aldose reductase
-
Bos taurus
ALR2
-
Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0314
-
i.e. 8-halogen-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid derivatives, synthesis and inhibitory potency, IC50 as low as 0.0314 mM, the length of the N2 alkanoic chain strongly influences the inhibitory activity, overview Bos taurus thienocinnolinone alkanoic acid derivatives