Inhibitors | Comment | Organism | Structure |
---|---|---|---|
8-bromo-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid | 4fold decreased inhibitory potency compared to the nonsubstituted parent compound | Bos taurus | |
8-chloro-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid | 4fold decreased inhibitory potency compared to the nonsubstituted parent compound | Bos taurus | |
8-methyl-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid | 2fold decreased inhibitory potency compared to the nonsubstituted parent compound | Bos taurus | |
thienocinnolinone alkanoic acid derivatives | i.e. 8-halogen-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid derivatives, synthesis and inhibitory potency, IC50 as low as 0.0314 mM, the length of the N2 alkanoic chain strongly influences the inhibitory activity, overview | Bos taurus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lens | - |
Bos taurus | - |
Synonyms | Comment | Organism |
---|---|---|
aldose reductase | - |
Bos taurus |
ALR2 | - |
Bos taurus |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0314 | - |
i.e. 8-halogen-4,4a-5,6-tetrahydrothieno[2,3-h]cinnolinone-N2-alkanoic acid derivatives, synthesis and inhibitory potency, IC50 as low as 0.0314 mM, the length of the N2 alkanoic chain strongly influences the inhibitory activity, overview | Bos taurus | thienocinnolinone alkanoic acid derivatives |