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Literature summary for 1.1.1.21 extracted from

  • Drel, V.R.; Pacher, P.; Stevens, M.J.; Obrosova, I.G.
    Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells (2006), Free Radic. Biol. Med., 40, 1454-1465.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
fidarestat i.e. inhibitor F, inhibition in vivo and in vitro Homo sapiens
fidarestat i.e. inhibitor F, inhibition in vivo and in vitro Rattus norvegicus
additional information enzyme inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in high-glucose exposed mesengial cells Homo sapiens
additional information enzyme inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic kidney cortex Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NADPH + H+ Homo sapiens increased enzyme activity and oxidative or nitrosative stress are involved in pathogenesis of diabetic nephropathy, overview alditol + NADP+
-
 ?
aldose + NADPH + H+ Rattus norvegicus increased enzyme activity and oxidative or nitrosative stress are involved in pathogenesis of diabetic nephropathy, overview alditol + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Homo sapiens
-
kidney
-
 Rattus norvegicus
-
mesangial cell
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 enzyme activity, and sorbitol, glucose, and fructose contents in mesangial cell, overview Homo sapiens
additional information
-
 enzyme activity, and sorbitol, glucose, and fructose contents in renal cortex of control and streptozotocin-diabetic rats, determination of nitrotyrosine in control and diabetic kidney, overview Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
aldose + NADPH + H+
-
 Homo sapiens alditol + NADP+
-
 ?
aldose + NADPH + H+
-
 Rattus norvegicus alditol + NADP+
-
 ?
aldose + NADPH + H+ increased enzyme activity and oxidative or nitrosative stress are involved in pathogenesis of diabetic nephropathy, overview Homo sapiens alditol + NADP+
-
 ?
aldose + NADPH + H+ increased enzyme activity and oxidative or nitrosative stress are involved in pathogenesis of diabetic nephropathy, overview Rattus norvegicus alditol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Homo sapiens
aldose reductase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Homo sapiens
NADPH
-
 Rattus norvegicus