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Literature summary for 1.1.1.21 extracted from

  • Srivastava, S.; Ramana, K.V.; Tammali, R.; Srivastava, S.K.; Bhatnagar, A.
    Contribution of aldose reductase to diabetic hyperproliferation of vascular smooth muscle cells (2006), Diabetes, 55, 901-910.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.1.1.21

Inhibitors

Inhibitors Comment Organism Structure
4-hydroxy-trans-2-nonenal
-
 Rattus norvegicus
sorbinil AR inhibitor, prevents hyperproliferation of aortic smooth muscle cells Rattus norvegicus
Tolrestat AR inhibitor, prevents hyperproliferation of aortic smooth muscle cells, cell cycle progression in the presence of high glucose was blocked by tolrestat Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus the enzyme regulates high-glucose-induced growth and contributes to diabetic hyperproliferation of vascular smooth muscle cells, inhibition of the enzyme also increases vascular oxidative stress, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
aorta
-
 Rattus norvegicus
-
smooth muscle vascular cell Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme regulates high-glucose-induced growth and contributes to diabetic hyperproliferation of vascular smooth muscle cells, inhibition of the enzyme also increases vascular oxidative stress, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
aldose reductase
-
 Rattus norvegicus