Any feedback?
Literature summary for 1.1.1.21 extracted from
- Isolation and characterization of aldose reductase from calf brain (1976), Biochim. Biophys. Acta, 452, 1-12.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| SO42- | stimulation | Bos taurus |  |
| SO42- | ammonium and lithium salt is somewhat more effective than sodium and potassium salt | Bos taurus | |
General Stability
| General Stability | Organism |
|---|---|
| -55°C, unstable to prolonged storage | Bos taurus |
| freezing and thawing: more than twice, unstable | Bos taurus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29000 | - |
isozyme AR I, gel filtration | Bos taurus |
| 30000 | - |
isozyme AR II, gel filtration | Bos taurus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| aldose + NAD(P)H | Bos taurus | - |
alditol + NAD(P)+ | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
| Bos taurus | - |
2 enzymes AR I (ALR 1) and AR II (ALR 2) | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| 2 enzymes: AR I and AR II | Bos taurus |
| calf | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.488 | - |
- |
Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| alditol + NAD(P)+ | - |
Bos taurus | aldose + NAD(P)H | - |
r | |
| aldose + NAD(P)H | - |
Bos taurus | alditol + NAD(P)+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 30000, isozyme AR I, SDS-PAGE, monomer is in equilibrium with a less effective dimer | Bos taurus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.6 | - |
DL-glyceraldehyde + NADPH | Bos taurus |
| 10 | - |
glycerol + NADP+ | Bos taurus |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 4.8 | 8.6 | 2 h, stable | Bos taurus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
