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Literature summary for 1.1.1.21 extracted from

  • Sheaff, C.M.; Doughty, C.C.
    Physical and kinetic properties of homogenous bovine lens aldose reductase (1976), J. Biol. Chem., 251, 2696-2702.
    View publication on PubMed
Search for more literature for 1.1.1.21

Activating Compound

Activating Compound Comment Organism Structure
SO42- stimulation Bos taurus

General Stability

General Stability Organism
extremely labile to freezing and thawing unless Carbowax 100 is included, 10 mg/ml Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
2'-AMP
-
 Bos taurus
glyceraldehyde substrate inhibition Bos taurus
NADP+
-
 Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37000
-
 gel filtration Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Bos taurus
-
 alditol + NAD(P)+
-
 r

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
lens
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Bos taurus

Storage Stability

Storage Stability Organism
-60°C, indefinitely Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alditol + NAD(P)+
-
 Bos taurus aldose + NAD(P)H
-
 r
aldose + NAD(P)H
-
 Bos taurus alditol + NAD(P)+
-
 r

Subunits

Subunits Comment Organism
monomer 1 * 37000, SDS-PAGE in presence of 2-mercaptoethanol Bos taurus