Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.21 extracted from

  • Wermuth, B.; Burgisser, H.; Bohren, K.; von Wartburg, J.P.
    Purification and characterization of human-brain aldose reductase (1982), Eur. J. Biochem., 127, 279-284.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
SO42- stimulation Homo sapiens

General Stability

General Stability Organism
freezing and thawing at temperatures above 50°C results in loss of activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
iodoacetate
-
Homo sapiens
p-hydroxymercuribenzoate
-
Homo sapiens
Phenobarbitone
-
Homo sapiens
quercetin
-
Homo sapiens
rutin
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
20alpha-Isocorticosterone and 20alpha-isocortisol, values below Homo sapiens
0.002
-
4-nitrobenzaldehyde
-
Homo sapiens
0.003
-
4-nitrobenzaldehyde 4-hydroxyphenylglycolaldehyde Homo sapiens
0.01
-
4-hydroxyphenylacetaldehyde
-
Homo sapiens
0.016
-
Indole-3-acetaldehyde
-
Homo sapiens
0.018
-
L-glyceraldehyde
-
Homo sapiens
0.025
-
DL-glyceraldehyde
-
Homo sapiens
0.035
-
D-glyceraldehyde
-
Homo sapiens
5
-
D-glucuronate
-
Homo sapiens
5.1
-
D-xylose
-
Homo sapiens
40
-
D-galactose
-
Homo sapiens
95
-
D-glucose
-
Homo sapiens
100
-
L-Xylose
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Homo sapiens
-
alditol + NAD(P)+
-
r
additional information Homo sapiens enzyme involved in metabolism of corticosteroids ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Storage Stability

Storage Stability Organism
4°C, several weeks Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
20-isocortisol + NAD(P)H
-
Homo sapiens ?
-
?
20alpha-isocorticosterone + NAD(P)H
-
Homo sapiens ?
-
?
4-hydroxyphenylacetaldehyde + NAD(P)H
-
Homo sapiens 4-hydroxyphenylethyl alcohol + NAD(P)+
-
?
4-hydroxyphenylglycolaldehyde + NAD(P)H
-
Homo sapiens ?
-
?
4-nitrobenzaldehyde + NAD(P)H
-
Homo sapiens 4-nitrobenzyl alcohol + NAD(P)+
-
?
alditol + NAD(P)+
-
Homo sapiens aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Homo sapiens alditol + NAD(P)+
-
r
D-galactose + NAD(P)H
-
Homo sapiens dulcitol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Homo sapiens sorbitol + NAD(P)+
-
r
D-glucuronate + NAD(P)H
-
Homo sapiens ?
-
r
D-glyceraldehyde + NAD(P)H
-
Homo sapiens glycerol + NAD(P)+
-
?
D-xylose + NAD(P)H
-
Homo sapiens xylitol + NAD(P)+
-
r
DL-glyceraldehyde + NAD(P)H
-
Homo sapiens glycerol + NAD(P)+
-
r
indole-3-acetaldehyde + NAD(P)H
-
Homo sapiens indole-3-ethanol + NAD(P)+
-
?
L-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
L-xylose + NAD(P)H
-
Homo sapiens L-xylitol + NAD(P)+
-
r
additional information oxidation of alcohols by NADP+ is negligible at 25°C, measurable at 37°C Homo sapiens ?
-
?
additional information enzyme involved in metabolism of corticosteroids Homo sapiens ?
-
?
phenylglyoxal + NAD(P)H
-
Homo sapiens ?
-
?
xylitol + NAD(P)+
-
Homo sapiens D-xylose + NAD(P)H + H+
-
r

Subunits

Subunits Comment Organism
monomer 1 * 38000, SDS-PAGE Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.55
-
D-glyceraldehyde
-
Homo sapiens
0.64
-
20alpha-Isocorticosterone 20alpha-isocortisol Homo sapiens
0.76
-
Phenylglyoxal
-
Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
5.1
-
90 min, 50% loss of activity Homo sapiens
6
-
unstable below Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH 5% Homo sapiens
NADPH
-
Homo sapiens