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Literature summary for 1.1.1.21 extracted from

  • Wermuth, B.; von Wartburg, J.P.
    Aldose reductase from human tissues (1982), Methods Enzymol., 89, 181-186.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
(NH4)2SO4 activation Homo sapiens
(NH4)2SO4 0.1 M Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
3,3-Tetramethylene glutaric acid
-
Homo sapiens
7-Hydroxy-4-oxo-4H-chromen-2-carboxylic acid
-
Homo sapiens
Alrestatin 1,3-dioxo-1H-benz[de]isoquinoline-2-(3H)acetic acid Homo sapiens
Cl-
-
Homo sapiens
quercetin
-
Homo sapiens
quercitrin
-
Homo sapiens
rutin
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
aldose + NAD(P)H Homo sapiens
-
alditol + NAD(P)+
-
r
additional information Homo sapiens enzyme of sorbitol (polyol) pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
heart
-
Homo sapiens
-
kidney
-
Homo sapiens
-
lens
-
Homo sapiens
-
lung
-
Homo sapiens
-
additional information no activity in human liver Homo sapiens
-
pancreas
-
Homo sapiens
-
placenta
-
Homo sapiens
-
testis
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.475
-
-
Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
11-deoxyisocorticosterone + NAD(P)H
-
Homo sapiens ?
-
?
2,3-bornanedione + NAD(P)H
-
Homo sapiens ?
-
?
20-isocortisol + NAD(P)H
-
Homo sapiens ?
-
?
20alpha-isocorticosterone + NAD(P)H
-
Homo sapiens ?
-
?
4-hydroxyphenylacetaldehyde + NAD(P)H
-
Homo sapiens 4-hydroxyphenylethyl alcohol + NAD(P)+
-
?
4-hydroxyphenylglycolaldehyde + NAD(P)H
-
Homo sapiens ?
-
?
4-nitrobenzaldehyde + NAD(P)H
-
Homo sapiens 4-nitrobenzyl alcohol + NAD(P)+
-
?
alditol + NAD(P)+
-
Homo sapiens aldose + NAD(P)H
-
r
aldose + NAD(P)H
-
Homo sapiens alditol + NAD(P)+
-
r
butyraldehyde + NAD(P)H
-
Homo sapiens butanol + NAD(P)+
-
?
D-galactose + NAD(P)H
-
Homo sapiens dulcitol + NAD(P)+
-
r
D-glucose + NAD(P)H
-
Homo sapiens sorbitol + NAD(P)+
-
r
D-glucuronate + NAD(P)H
-
Homo sapiens ?
-
r
D-xylose + NAD(P)H
-
Homo sapiens xylitol + NAD(P)+
-
r
decanal + NAD(P)H
-
Homo sapiens decanol + NAD(P)+
-
?
indole-3-acetaldehyde + NAD(P)H
-
Homo sapiens indole-3-ethanol + NAD(P)+
-
?
additional information oxidation of polyols to polyolaldehydes by NADP+ proceeds very slowly Homo sapiens ?
-
?
additional information enzyme of sorbitol (polyol) pathway Homo sapiens ?
-
?
xylitol + NAD(P)+
-
Homo sapiens D-xylose + NAD(P)H + H+
-
r

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6 7 aldehyde reduction Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
5
-
4°C, unstable below Homo sapiens
6 9 4°C, several days, stable Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADH 10% of the NADPH-dependent activity Homo sapiens
NADP+
-
Homo sapiens
NADPH NADPH-specific, pro-4R hydrogen is transferred from the nicotinamide ring of the coenzyme to the substrate Homo sapiens