Activating Compound | Comment | Organism | Structure |
---|---|---|---|
(NH4)2SO4 | activation | Homo sapiens | |
(NH4)2SO4 | 0.1 M | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3,3-Tetramethylene glutaric acid | - |
Homo sapiens | |
7-Hydroxy-4-oxo-4H-chromen-2-carboxylic acid | - |
Homo sapiens | |
Alrestatin | 1,3-dioxo-1H-benz[de]isoquinoline-2-(3H)acetic acid | Homo sapiens | |
Cl- | - |
Homo sapiens | |
quercetin | - |
Homo sapiens | |
quercitrin | - |
Homo sapiens | |
rutin | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
aldose + NAD(P)H | Homo sapiens | - |
alditol + NAD(P)+ | - |
r | |
additional information | Homo sapiens | enzyme of sorbitol (polyol) pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
lens | - |
Homo sapiens | - |
lung | - |
Homo sapiens | - |
additional information | no activity in human liver | Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
placenta | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.475 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-deoxyisocorticosterone + NAD(P)H | - |
Homo sapiens | ? | - |
? | |
2,3-bornanedione + NAD(P)H | - |
Homo sapiens | ? | - |
? | |
20-isocortisol + NAD(P)H | - |
Homo sapiens | ? | - |
? | |
20alpha-isocorticosterone + NAD(P)H | - |
Homo sapiens | ? | - |
? | |
4-hydroxyphenylacetaldehyde + NAD(P)H | - |
Homo sapiens | 4-hydroxyphenylethyl alcohol + NAD(P)+ | - |
? | |
4-hydroxyphenylglycolaldehyde + NAD(P)H | - |
Homo sapiens | ? | - |
? | |
4-nitrobenzaldehyde + NAD(P)H | - |
Homo sapiens | 4-nitrobenzyl alcohol + NAD(P)+ | - |
? | |
alditol + NAD(P)+ | - |
Homo sapiens | aldose + NAD(P)H | - |
r | |
aldose + NAD(P)H | - |
Homo sapiens | alditol + NAD(P)+ | - |
r | |
butyraldehyde + NAD(P)H | - |
Homo sapiens | butanol + NAD(P)+ | - |
? | |
D-galactose + NAD(P)H | - |
Homo sapiens | dulcitol + NAD(P)+ | - |
r | |
D-glucose + NAD(P)H | - |
Homo sapiens | sorbitol + NAD(P)+ | - |
r | |
D-glucuronate + NAD(P)H | - |
Homo sapiens | ? | - |
r | |
D-xylose + NAD(P)H | - |
Homo sapiens | xylitol + NAD(P)+ | - |
r | |
decanal + NAD(P)H | - |
Homo sapiens | decanol + NAD(P)+ | - |
? | |
indole-3-acetaldehyde + NAD(P)H | - |
Homo sapiens | indole-3-ethanol + NAD(P)+ | - |
? | |
additional information | oxidation of polyols to polyolaldehydes by NADP+ proceeds very slowly | Homo sapiens | ? | - |
? | |
additional information | enzyme of sorbitol (polyol) pathway | Homo sapiens | ? | - |
? | |
xylitol + NAD(P)+ | - |
Homo sapiens | D-xylose + NAD(P)H + H+ | - |
r |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6 | 7 | aldehyde reduction | Homo sapiens |
pH Stability | pH Stability Maximum | Comment | Organism |
---|---|---|---|
5 | - |
4°C, unstable below | Homo sapiens |
6 | 9 | 4°C, several days, stable | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | 10% of the NADPH-dependent activity | Homo sapiens | |
NADP+ | - |
Homo sapiens | |
NADPH | NADPH-specific, pro-4R hydrogen is transferred from the nicotinamide ring of the coenzyme to the substrate | Homo sapiens |