Literature summary for 1.1.1.205 extracted from

Bremer, S.; Mandla, R.; Vethe, N.T.; Rasmussen, I.; Rootwelt, H.; Line, P.D.; Midtvedt, K.; Bergan, S.
Expression of IMPDH1 and IMPDH2 after transplantation and initiation of immunosuppression (2008), Transplantation, 85, 55-61.

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Application

Application	Comment	Organism
medicine	in renal transplant patients, transplantation and initiation of immunosuppressive therapy is associated with increased isoform IMPDH1 and decreased IMPDH2 expression. In CD4+ cells, however, IMPDH2 expression increases. Two weeks posttransplant, mycophenolic acid-treated patients display elevated IMPDH1 and IMPDH2 expression in reticulocyte. Patients with acute rejection during follow-up demonstrate higher IMPDH2 expression in Cd4+ cells pretransplant than nonrejecting patients	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	renal transplant patients	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
blood	-	Homo sapiens	-
reticulocyte	-	Homo sapiens	-
T-cell	CD4+	Homo sapiens	-

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Release 2023.1 (January 2023)