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Literature summary for 1.1.1.205 extracted from

  • Chen, L.; Gao, G.; Felczak, K.; Bonnac, L.; Patterson, S.E.; Wilson, D.; Bennett, E.M.; Jayaram, H.N.; Hedstrom, L.; Pankiewicz, K.W.
    Probing binding requirements of type I and type II isoforms of inosine monophosphate dehydrogenase with adenine-modified nicotinamide adenine dinucleotide analogues (2007), J. Med. Chem., 50, 5743-5751.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
molecular modeling of type II enzyme in complex with inhibitor 1_1_1.205_2.3 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
P1-(tiazofurin-5'-yl)-P2-(2-aminoadenosin-5'-yl) diphosphate comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation Homo sapiens
P1-(tiazofurin-5'-yl)-P2-(2-ethyladenosin-5'-yl) diphosphate comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation Homo sapiens
P1-(tiazofurin-5'-yl)-P2-(2-ethynyladenosin-5'-yl) diphosphate comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation Homo sapiens
P1-(tiazofurin-5'-yl)-P2-(2-iodoadenosin-5'-yl) diphosphate comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation Homo sapiens
P1-(tiazofurin-5'-yl)-P2-(2-phenyladenosin-5'-yl) diphosphate comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation Homo sapiens
P1-(tiazofurin-5'-yl)-P2-(adenosin-5'-yl) diphosphate comparison with inhibition of alcohol dehydrogenase, malate dehydrogenase, lactate dehydrogenase and K562 cell proliferation Homo sapiens
P1-[7-hydroxy-6-(hydroxyethyl)-5-methoxy-4-methylphthtalan-1-one-2-yl]-P2-(2-ethyladenosin-5'-yl)methylenebis(phosphonate)
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000001
-
P1-(tiazofurin-5'-yl)-P2-(2-ethyladenosin-5'-yl) diphosphate isoform IMPDH1, pH 8.0, 25°C Homo sapiens
0.000007
-
P1-(tiazofurin-5'-yl)-P2-(2-aminoadenosin-5'-yl) diphosphate isoform IMPDH1, pH 8.0, 25°C Homo sapiens
0.00001
-
P1-(tiazofurin-5'-yl)-P2-(2-ethynyladenosin-5'-yl) diphosphate isoform IMPDH1, pH 8.0, 25°C Homo sapiens
0.000014
-
P1-(tiazofurin-5'-yl)-P2-(2-ethyladenosin-5'-yl) diphosphate isoform IMPDH2, pH 8.0, 25°C Homo sapiens
0.000019
-
P1-(tiazofurin-5'-yl)-P2-(2-iodoadenosin-5'-yl) diphosphate isoform IMPDH1, pH 8.0, 25°C Homo sapiens
0.00002
-
P1-(tiazofurin-5'-yl)-P2-(2-phenyladenosin-5'-yl) diphosphate isoform IMPDH1, pH 8.0, 25°C Homo sapiens
0.000027
-
P1-(tiazofurin-5'-yl)-P2-(2-aminoadenosin-5'-yl) diphosphate isoform IMPDH2, pH 8.0, 25°C Homo sapiens
0.000049
-
P1-(tiazofurin-5'-yl)-P2-(2-ethynyladenosin-5'-yl) diphosphate isoform IMPDH2, pH 8.0, 25°C Homo sapiens
0.000084
-
P1-(tiazofurin-5'-yl)-P2-(2-iodoadenosin-5'-yl) diphosphate isoform IMPDH2, pH 8.0, 25°C Homo sapiens
0.00011
-
P1-(tiazofurin-5'-yl)-P2-(adenosin-5'-yl) diphosphate isoform IMPDH1, pH 8.0, 25°C Homo sapiens
0.00011
-
P1-(tiazofurin-5'-yl)-P2-(adenosin-5'-yl) diphosphate isoform IMPDH2, pH 8.0, 25°C Homo sapiens
0.000143
-
P1-(tiazofurin-5'-yl)-P2-(2-phenyladenosin-5'-yl) diphosphate isoform IMPDH2, pH 8.0, 25°C Homo sapiens
0.04
-
P1-[7-hydroxy-6-(hydroxyethyl)-5-methoxy-4-methylphthtalan-1-one-2-yl]-P2-(2-ethyladenosin-5'-yl)methylenebis(phosphonate) isoform IMPDH2, pH 8.0, 25°C Homo sapiens