Literature summary for 1.1.1.205 extracted from

Rejman, D.; Olesiak, M.; Chen, L.; Patterson, S.E.; Wilson, D.; Jayaram, H.N.; Hedstrom, L.; Pankiewicz, K.W.
Novel methylenephosphophosphonate analogues of mycophenolic adenine dinucleotide. Inhibition of inosine monophosphate dehydrogenase (2006), J. Med. Chem., 49, 5018-5022.

Search for more literature for 1.1.1.205

Application

Application	Comment	Organism
drug development	the enzyme is a target for therapeutic drugs	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
C2-mycophenolic adenine dinucleotide	methylenephosphophosphonate analogue of mycophenolic adenine dinucleotide	Homo sapiens
C4-mycophenolic adenine dinucleotide	methylenephosphophosphonate analogue of mycophenolic adenine dinucleotide	Homo sapiens
mizoribine	-	Homo sapiens
additional information	inhibitor development and synthesis, overview	Homo sapiens
Mycophenolic acid	-	Homo sapiens
mycophenolic adenine dinucleotide	-	Homo sapiens
P1-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)methylenephospho-P2-(adenosin-5'-yl)phosphonate	-	Homo sapiens
P1-(adenosine-5'-yl)methylenephospho-P2-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)phosphonate	-	Homo sapiens
ribavirin	-	Homo sapiens
tiazofurin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
IMPDH	-	Homo sapiens
inosine monophosphate dehydrogenase	-	Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	assay at	Homo sapiens

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.02	0.037	P1-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)methylenephospho-P2-(adenosin-5'-yl)phosphonate	pH 8.0, 25°C	Homo sapiens
0.06	0.087	P1-(adenosine-5'-yl)methylenephospho-P2-(7-hydroxy-6-(ethyl-2-yl)-5-methoxy-4-methylphthalan-1-one)phosphonate	pH 8.0, 25°C	Homo sapiens
0.25	0.33	C2-mycophenolic adenine dinucleotide	pH 8.0, 25°C	Homo sapiens
0.38	0.52	C4-mycophenolic adenine dinucleotide	pH 8.0, 25°C	Homo sapiens

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Release 2023.1 (January 2023)