Protein Variants | Comment | Organism |
---|---|---|
E431Q | 6fold decrease of Ki for mycophenolic acid | Tritrichomonas suis |
K310R | 10fold decrease of Ki for mycophenolic acid, increase of Km for IMP and NAD+ | Tritrichomonas suis |
K310R/E431Q | 20fold increase in sensitivity to mycophenolic acid | Tritrichomonas suis |
Q441E | less than 0.045% of wild type activity, therefore no further characterization possible | Homo sapiens |
R322K | less than 0.045% of wild type activity, therefore no further characterization possible | Homo sapiens |
R322K/Q441E | less than 0.045% of wild type activity, therefore no further characterization possible | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Mycophenolic acid | - |
Homo sapiens | |
Mycophenolic acid | - |
Tritrichomonas suis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Tritrichomonas suis | - |
wild type and mutants | - |
Purification (Comment) | Organism |
---|---|
- |
Tritrichomonas suis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | wild type and mutants | Homo sapiens | |
additional information | - |
additional information | wild type and mutants | Tritrichomonas suis |