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Literature summary for 1.1.1.205 extracted from

  • Heyde, E.; Morrison, J.F.
    Studies on inosine monophosphate dehydrogenase. An associating-dissociating system (1976), Biochim. Biophys. Acta, 429, 635-644.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
Reducing agent effectiveness decreases in the order: dithiothreitol, mercaptoethanol, cyanide, ascorbate Klebsiella aerogenes

Inhibitors

Inhibitors Comment Organism Structure
Urea inactive at 3 M but regains activity after dialysis Klebsiella aerogenes

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38000
-
2 * 38000, amino acid analysis Klebsiella aerogenes
86000
-
smallest active species has a molecular weight of 86000, after polymerization in the absence of reducing agents the largest species has a molecular weight of 248000, gel filtration Klebsiella aerogenes

Organism

Organism UniProt Comment Textmining
Klebsiella aerogenes
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Klebsiella aerogenes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
Klebsiella aerogenes xanthosine 5'-phosphate + NADH
-
?

Subunits

Subunits Comment Organism
? multiples with a basic unit of 160000 Klebsiella aerogenes
dimer 2 * 38000, amino acid analysis Klebsiella aerogenes

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Klebsiella aerogenes