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Literature summary for 1.1.1.205 extracted from

  • Robins, R.K.; Revankar, G.R.; McKernan, P.A.; Murray, B.K.; Kirsi, J.J.; North, J.A.
    The importance of IMP dehydrogenase inhibition in the broad spectrum antiviral activity of ribavirin and selenazofurin (1985), Adv. Enzyme Regul., 24, 29-43.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Bredinin
-
Chlorocebus aethiops
ribavirin potent competitive inhibition, shows anti-viral activity in vivo, detailed overview Parainfluenza virus
ribavirin potent competitive inhibition, shows anti-viral activity in vivo, detailed overview Vaccinia virus
ribavirin 5'-monophosphate
-
Chlorocebus aethiops
Selenazofurin inhibition (in vivo) by the NAD analog formed intracellularly Chlorocebus aethiops
Selenazofurin potent competitive inhibition, shows anti-viral activity in vivo, detailed overview, a complete reversal of the antiviral activity of selenazofurin was obtained by addition of guanosine and selenazofurin at varying concentrations Parainfluenza virus
Selenazofurin potent competitive inhibition, shows anti-viral activity in vivo, detailed overview Vaccinia virus
thiazole-4-carboxamide adenine dinucleotide
-
Chlorocebus aethiops
tiazofurin
-
Chlorocebus aethiops
tiazofurin
-
Parainfluenza virus
tiazofurin
-
Vaccinia virus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O Vaccinia virus rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview xanthosine 5'-phosphate + NADH
-
?
inosine 5'-phosphate + NAD+ + H2O Parainfluenza virus rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview xanthosine 5'-phosphate + NADH
-
?
inosine 5'-phosphate + NAD+ + H2O Vaccinia virus Elstree rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview xanthosine 5'-phosphate + NADH
-
?

Organism

Organism UniProt Comment Textmining
Chlorocebus aethiops
-
vero cell-line infected with vaccina virus and parainfluenza virus type 3 strain C243
-
Parainfluenza virus
-
type 3, strain C243, propagated in Vero cells
-
Vaccinia virus
-
propagated in Vero cells
-
Vaccinia virus Elstree
-
propagated in Vero cells
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
inosine 5'-phosphate + NAD+ + H2O
-
Vaccinia virus xanthosine 5'-phosphate + NADH
-
?
inosine 5'-phosphate + NAD+ + H2O
-
Chlorocebus aethiops xanthosine 5'-phosphate + NADH
-
?
inosine 5'-phosphate + NAD+ + H2O
-
Parainfluenza virus xanthosine 5'-phosphate + NADH
-
?
inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview Vaccinia virus xanthosine 5'-phosphate + NADH
-
?
inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview Parainfluenza virus xanthosine 5'-phosphate + NADH
-
?
inosine 5'-phosphate + NAD+ + H2O
-
Vaccinia virus Elstree xanthosine 5'-phosphate + NADH
-
?
inosine 5'-phosphate + NAD+ + H2O rate-limiting step of the de novo guanine nucleotide biosynthesis, pathway overview Vaccinia virus Elstree xanthosine 5'-phosphate + NADH
-
?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Chlorocebus aethiops
NAD+
-
Parainfluenza virus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00025
-
ribavirin 5'-monophosphate
-
Chlorocebus aethiops