BRENDA - Enzyme Database
show all sequences of 1.1.1.2

Localization, isolation and properties of three NADPH-dependent aldehyde reducing enzymes from dog kidney

Ohta, M.; Tanimoto, T.; Tanaka, A.; Biochim. Biophys. Acta 1078, 395-403 (1991)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
Alconil
-
Rattus norvegicus
Alconil
-
Canis lupus familiaris
epalrestat
-
Rattus norvegicus
epalrestat
-
Canis lupus familiaris
M79175
-
Canis lupus familiaris
ponalrestat
-
Homo sapiens
ponalrestat
-
Canis lupus familiaris
sodium valproate
-
Homo sapiens
sodium valproate
-
Bos taurus
sodium valproate
-
Canis lupus familiaris
sodium valproate
-
Ovis aries
sorbinil
-
Homo sapiens
sorbinil
-
Rattus norvegicus
sorbinil
-
Ovis aries
sorbinil
-
Canis lupus familiaris
Tolrestat
-
Rattus norvegicus
Tolrestat
-
Homo sapiens
Tolrestat
-
Canis lupus familiaris
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.5
-
D-glucuronate
outer medulla enzyme
Canis lupus familiaris
3.22
-
D-glucuronate
inner medulla enzyme
Canis lupus familiaris
3.34
-
D-glucuronate
cortex enzyme
Canis lupus familiaris
4.67
-
DL-glyceraldehyde
inner medulla enzyme
Canis lupus familiaris
4.68
-
DL-glyceraldehyde
cortex enzyme
Canis lupus familiaris
5.92
-
DL-glyceraldehyde
outer medulla enzyme
Canis lupus familiaris
845
-
D-xylose
outer medulla enzyme
Canis lupus familiaris
1152
-
D-xylose
inner medulla enzyme
Canis lupus familiaris
1497
-
D-xylose
cortex enzyme
Canis lupus familiaris
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
40000
-
gel filtration
Canis lupus familiaris
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
D-glucuronate + NADPH
Cavia porcellus
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Mus musculus
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Homo sapiens
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Rattus norvegicus
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Sus scrofa
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Bos taurus
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Oryctolagus cuniculus
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Ovis aries
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Canis lupus familiaris
-
L-gulonate + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Cavia porcellus
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Mus musculus
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Homo sapiens
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Rattus norvegicus
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Sus scrofa
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Oryctolagus cuniculus
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Ovis aries
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Canis lupus familiaris
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Cavia porcellus
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Mus musculus
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Homo sapiens
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Rattus norvegicus
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Sus scrofa
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Oryctolagus cuniculus
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Ovis aries
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Canis lupus familiaris
-
glycerol + NADP+
-
-
r
Organism
Organism
UniProt
Commentary
Textmining
Bos taurus
-
bovine
-
Canis lupus familiaris
-
-
-
Cavia porcellus
-
guinea pig
-
Homo sapiens
-
human
-
Mus musculus
-
mouse
-
Oryctolagus cuniculus
-
rabbit
-
Ovis aries
-
sheep; Suffolk-Hampshire
-
Rattus norvegicus
-
rat
-
Sus scrofa
-
pig
-
Purification (Commentary)
Purification (Commentary)
Organism
-
Canis lupus familiaris
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Sus scrofa
-
kidney
-
Homo sapiens
-
kidney
-
Bos taurus
-
kidney
-
Oryctolagus cuniculus
-
kidney
-
Mus musculus
-
kidney
-
Ovis aries
-
kidney
-
Cavia porcellus
-
kidney
renal cortex, outer medulla and inner medulla
Canis lupus familiaris
-
kidney
renal cortex
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.35
-
-
Canis lupus familiaris
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
D-glucuronate + NADPH
-
286196
Cavia porcellus
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Cavia porcellus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Mus musculus
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Mus musculus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Homo sapiens
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Homo sapiens
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Rattus norvegicus
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Rattus norvegicus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Sus scrofa
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Sus scrofa
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Bos taurus
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Bos taurus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Oryctolagus cuniculus
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Oryctolagus cuniculus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Ovis aries
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Ovis aries
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Canis lupus familiaris
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Canis lupus familiaris
L-gulonate + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Cavia porcellus
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Mus musculus
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Homo sapiens
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Rattus norvegicus
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Sus scrofa
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Oryctolagus cuniculus
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Ovis aries
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Canis lupus familiaris
glycerol + NADP+
-
-
-
r
D-xylose + NADPH
-
286196
Rattus norvegicus
? + NADP+
-
-
-
?
D-xylose + NADPH
-
286196
Sus scrofa
? + NADP+
-
-
-
?
D-xylose + NADPH
-
286196
Bos taurus
? + NADP+
-
-
-
?
D-xylose + NADPH
-
286196
Canis lupus familiaris
? + NADP+
-
-
-
?
L-glyceraldehyde + NADPH
-
286196
Cavia porcellus
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Mus musculus
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Homo sapiens
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Rattus norvegicus
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Sus scrofa
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Oryctolagus cuniculus
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Ovis aries
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Canis lupus familiaris
glycerol + NADP+
-
-
-
r
additional information
-
286196
Homo sapiens
?
-
-
-
-
additional information
-
286196
Sus scrofa
?
-
-
-
-
additional information
-
286196
Bos taurus
?
-
-
-
-
additional information
D-hexose is no substrate
286196
Canis lupus familiaris
?
-
-
-
-
Cofactor
Cofactor
Commentary
Organism
Structure
NADPH
-
Bos taurus
NADPH
-
Canis lupus familiaris
NADPH
-
Homo sapiens
Cofactor (protein specific)
Cofactor
Commentary
Organism
Structure
NADPH
-
Bos taurus
NADPH
-
Canis lupus familiaris
NADPH
-
Homo sapiens
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
Alconil
-
Rattus norvegicus
Alconil
-
Canis lupus familiaris
epalrestat
-
Rattus norvegicus
epalrestat
-
Canis lupus familiaris
M79175
-
Canis lupus familiaris
ponalrestat
-
Homo sapiens
ponalrestat
-
Canis lupus familiaris
sodium valproate
-
Homo sapiens
sodium valproate
-
Bos taurus
sodium valproate
-
Canis lupus familiaris
sodium valproate
-
Ovis aries
sorbinil
-
Homo sapiens
sorbinil
-
Rattus norvegicus
sorbinil
-
Ovis aries
sorbinil
-
Canis lupus familiaris
Tolrestat
-
Rattus norvegicus
Tolrestat
-
Homo sapiens
Tolrestat
-
Canis lupus familiaris
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
2.5
-
D-glucuronate
outer medulla enzyme
Canis lupus familiaris
3.22
-
D-glucuronate
inner medulla enzyme
Canis lupus familiaris
3.34
-
D-glucuronate
cortex enzyme
Canis lupus familiaris
4.67
-
DL-glyceraldehyde
inner medulla enzyme
Canis lupus familiaris
4.68
-
DL-glyceraldehyde
cortex enzyme
Canis lupus familiaris
5.92
-
DL-glyceraldehyde
outer medulla enzyme
Canis lupus familiaris
845
-
D-xylose
outer medulla enzyme
Canis lupus familiaris
1152
-
D-xylose
inner medulla enzyme
Canis lupus familiaris
1497
-
D-xylose
cortex enzyme
Canis lupus familiaris
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
40000
-
gel filtration
Canis lupus familiaris
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
D-glucuronate + NADPH
Cavia porcellus
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Mus musculus
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Homo sapiens
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Rattus norvegicus
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Sus scrofa
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Bos taurus
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Oryctolagus cuniculus
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Ovis aries
-
L-gulonate + NADP+
-
-
r
D-glucuronate + NADPH
Canis lupus familiaris
-
L-gulonate + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Cavia porcellus
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Mus musculus
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Homo sapiens
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Rattus norvegicus
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Sus scrofa
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Oryctolagus cuniculus
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Ovis aries
-
glycerol + NADP+
-
-
r
D-glyceraldehyde + NADPH + H+
Canis lupus familiaris
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Cavia porcellus
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Mus musculus
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Homo sapiens
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Rattus norvegicus
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Sus scrofa
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Oryctolagus cuniculus
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Ovis aries
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Canis lupus familiaris
-
glycerol + NADP+
-
-
r
Purification (Commentary) (protein specific)
Commentary
Organism
-
Canis lupus familiaris
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Sus scrofa
-
kidney
-
Homo sapiens
-
kidney
-
Bos taurus
-
kidney
-
Oryctolagus cuniculus
-
kidney
-
Mus musculus
-
kidney
-
Ovis aries
-
kidney
-
Cavia porcellus
-
kidney
renal cortex, outer medulla and inner medulla
Canis lupus familiaris
-
kidney
renal cortex
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.35
-
-
Canis lupus familiaris
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
D-glucuronate + NADPH
-
286196
Cavia porcellus
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Cavia porcellus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Mus musculus
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Mus musculus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Homo sapiens
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Homo sapiens
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Rattus norvegicus
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Rattus norvegicus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Sus scrofa
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Sus scrofa
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Bos taurus
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Bos taurus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Oryctolagus cuniculus
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Oryctolagus cuniculus
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Ovis aries
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Ovis aries
L-gulonate + NADP+
-
-
-
r
D-glucuronate + NADPH
-
286196
Canis lupus familiaris
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286196
Canis lupus familiaris
L-gulonate + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Cavia porcellus
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Mus musculus
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Homo sapiens
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Rattus norvegicus
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Sus scrofa
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Oryctolagus cuniculus
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Ovis aries
glycerol + NADP+
-
-
-
r
D-glyceraldehyde + NADPH + H+
-
286196
Canis lupus familiaris
glycerol + NADP+
-
-
-
r
D-xylose + NADPH
-
286196
Rattus norvegicus
? + NADP+
-
-
-
?
D-xylose + NADPH
-
286196
Sus scrofa
? + NADP+
-
-
-
?
D-xylose + NADPH
-
286196
Bos taurus
? + NADP+
-
-
-
?
D-xylose + NADPH
-
286196
Canis lupus familiaris
? + NADP+
-
-
-
?
L-glyceraldehyde + NADPH
-
286196
Cavia porcellus
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Mus musculus
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Homo sapiens
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Rattus norvegicus
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Sus scrofa
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Oryctolagus cuniculus
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Ovis aries
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286196
Canis lupus familiaris
glycerol + NADP+
-
-
-
r
additional information
-
286196
Homo sapiens
?
-
-
-
-
additional information
-
286196
Sus scrofa
?
-
-
-
-
additional information
-
286196
Bos taurus
?
-
-
-
-
additional information
D-hexose is no substrate
286196
Canis lupus familiaris
?
-
-
-
-
Other publictions for EC 1.1.1.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)