BRENDA - Enzyme Database
show all sequences of 1.1.1.2

The kinetic mechanism of the major form of ox kidney aldehyde reductase with D-glucuronic acid

Daly, A.K.; Mantle, T.J.; Biochem. J. 205, 381-388 (1982)

Data extracted from this reference:

Inhibitors
Inhibitors
Commentary
Organism
Structure
benzoic acid
-
Bos taurus
L-Gulonic acid
product inhibition
Bos taurus
NADP+
product inhibition
Bos taurus
NADPH
product inhibition
Bos taurus
NADPH
-
Sus scrofa
sodium valproate
-
Bos taurus
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
D-glucuronate + NADPH
Sus scrofa
-
L-gulonate + NADP+
-
-
-
D-glucuronate + NADPH
Bos taurus
-
L-gulonate + NADP+
-
-
-
D-glyceraldehyde + NADPH + H+
Sus scrofa
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Sus scrofa
-
glycerol + NADP+
-
-
r
L-gulonic acid + NADP+
Sus scrofa
-
D-glucuronic acid + NADPH
-
-
-
L-gulonic acid + NADP+
Bos taurus
-
D-glucuronic acid + NADPH
-
-
-
succinic semialdehyde + NADPH + H+
Sus scrofa
-
4-hydroxybutyrate + NADP+
-
-
r
succinic semialdehyde + NADPH + H+
Bos taurus
-
4-hydroxybutyrate + NADP+
-
-
r
Organism
Organism
UniProt
Commentary
Textmining
Bos taurus
-
ox
-
Saccharomyces cerevisiae
-
yeast
-
Sus scrofa
-
pig
-
Source Tissue
Source Tissue
Commentary
Organism
Textmining
kidney
-
Sus scrofa
-
kidney
-
Bos taurus
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
3-pyridinecarboxaldehyde + NADPH
-
286179
Sus scrofa
3-pyridinemethanol + NADP+
-
-
-
r
3-pyridinecarboxaldehyde + NADPH
-
286179
Bos taurus
3-pyridinemethanol + NADP+
-
-
-
-
D-glucuronate + NADPH
-
286179
Sus scrofa
L-gulonate + NADP+
-
-
-
-
D-glucuronate + NADPH
-
286179
Sus scrofa
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286179
Bos taurus
L-gulonate + NADP+
-
-
-
-
D-glucuronate + NADPH
-
286179
Bos taurus
L-gulonate + NADP+
-
-
-
?
D-glyceraldehyde + NADPH + H+
-
286179
Sus scrofa
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286179
Sus scrofa
glycerol + NADP+
-
-
-
r
L-gulonic acid + NADP+
-
286179
Sus scrofa
D-glucuronic acid + NADPH
-
-
-
-
L-gulonic acid + NADP+
-
286179
Bos taurus
D-glucuronic acid + NADPH
-
-
-
-
L-gulonic acid + NADPH
-
286179
Sus scrofa
D-glucuronic acid + NADP+
-
-
-
-
L-gulonic acid + NADPH
-
286179
Bos taurus
D-glucuronic acid + NADP+
-
-
-
-
p-nitrobenzaldehyde + NADPH
-
286179
Sus scrofa
p-nitrobenzylalcohol + NADP+
-
-
-
r
p-nitrobenzaldehyde + NADPH
-
286179
Bos taurus
p-nitrobenzylalcohol + NADP+
-
-
-
r
succinic semialdehyde + NADPH + H+
-
286179
Sus scrofa
4-hydroxybutyrate + NADP+
-
-
-
r
succinic semialdehyde + NADPH + H+
-
286179
Bos taurus
4-hydroxybutyrate + NADP+
-
-
-
r
Synonyms
Synonyms
Commentary
Organism
yeast alcohol dehydrogenase
-
Saccharomyces cerevisiae
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
benzoic acid
-
Bos taurus
L-Gulonic acid
product inhibition
Bos taurus
NADP+
product inhibition
Bos taurus
NADPH
product inhibition
Bos taurus
NADPH
-
Sus scrofa
sodium valproate
-
Bos taurus
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ID
D-glucuronate + NADPH
Sus scrofa
-
L-gulonate + NADP+
-
-
-
D-glucuronate + NADPH
Bos taurus
-
L-gulonate + NADP+
-
-
-
D-glyceraldehyde + NADPH + H+
Sus scrofa
-
glycerol + NADP+
-
-
r
L-glyceraldehyde + NADPH
Sus scrofa
-
glycerol + NADP+
-
-
r
L-gulonic acid + NADP+
Sus scrofa
-
D-glucuronic acid + NADPH
-
-
-
L-gulonic acid + NADP+
Bos taurus
-
D-glucuronic acid + NADPH
-
-
-
succinic semialdehyde + NADPH + H+
Sus scrofa
-
4-hydroxybutyrate + NADP+
-
-
r
succinic semialdehyde + NADPH + H+
Bos taurus
-
4-hydroxybutyrate + NADP+
-
-
r
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
kidney
-
Sus scrofa
-
kidney
-
Bos taurus
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
3-pyridinecarboxaldehyde + NADPH
-
286179
Sus scrofa
3-pyridinemethanol + NADP+
-
-
-
r
3-pyridinecarboxaldehyde + NADPH
-
286179
Bos taurus
3-pyridinemethanol + NADP+
-
-
-
-
D-glucuronate + NADPH
-
286179
Sus scrofa
L-gulonate + NADP+
-
-
-
-
D-glucuronate + NADPH
-
286179
Sus scrofa
L-gulonate + NADP+
-
-
-
?
D-glucuronate + NADPH
-
286179
Bos taurus
L-gulonate + NADP+
-
-
-
-
D-glucuronate + NADPH
-
286179
Bos taurus
L-gulonate + NADP+
-
-
-
?
D-glyceraldehyde + NADPH + H+
-
286179
Sus scrofa
glycerol + NADP+
-
-
-
r
L-glyceraldehyde + NADPH
-
286179
Sus scrofa
glycerol + NADP+
-
-
-
r
L-gulonic acid + NADP+
-
286179
Sus scrofa
D-glucuronic acid + NADPH
-
-
-
-
L-gulonic acid + NADP+
-
286179
Bos taurus
D-glucuronic acid + NADPH
-
-
-
-
L-gulonic acid + NADPH
-
286179
Sus scrofa
D-glucuronic acid + NADP+
-
-
-
-
L-gulonic acid + NADPH
-
286179
Bos taurus
D-glucuronic acid + NADP+
-
-
-
-
p-nitrobenzaldehyde + NADPH
-
286179
Sus scrofa
p-nitrobenzylalcohol + NADP+
-
-
-
r
p-nitrobenzaldehyde + NADPH
-
286179
Bos taurus
p-nitrobenzylalcohol + NADP+
-
-
-
r
succinic semialdehyde + NADPH + H+
-
286179
Sus scrofa
4-hydroxybutyrate + NADP+
-
-
-
r
succinic semialdehyde + NADPH + H+
-
286179
Bos taurus
4-hydroxybutyrate + NADP+
-
-
-
r
Other publictions for EC 1.1.1.2
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Synonyms
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)