Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.1.1.2 extracted from

  • Wermuth, B.; Muench, J.D.B.; von Wartburg, J.P.
    Purification and properties of NADPH-dependent aldehyde reductase from human liver (1977), J. Biol. Chem., 252, 3821-3828.
    View publication on PubMed

General Stability

General Stability Organism
presence of NADPH or NADP+ prevents loss of activity Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
ethylphenylhydantoin
-
Homo sapiens
Phenobarbital
-
Homo sapiens
Phenobarbital
-
Sus scrofa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.025
-
p-Carboxybenzaldehyde
-
Homo sapiens
0.15
-
p-nitrobenzaldehyde
-
Homo sapiens
0.94
-
p-chlorobenzaldehyde
-
Homo sapiens
1.3
-
methylglyoxal
-
Homo sapiens
1.3
-
Butyraldehyde
-
Homo sapiens
1.4
-
Camphorquinone
-
Homo sapiens
1.5
-
DL-glyceraldehyde
-
Homo sapiens
2.4
-
m-nitrobenzaldehyde
-
Homo sapiens
2.9
-
propionaldehyde
-
Homo sapiens
3.4
-
benzaldehyde
-
Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
30000
-
-
Sus scrofa
30000
-
gel filtration Homo sapiens
33600
-
sedimentation analysis Homo sapiens
36200
-
gel filtration Homo sapiens
36300
-
ultracentrifugation Homo sapiens
39400
-
1 * 39400, SDS-PAGE Homo sapiens
44000
-
gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-glyceraldehyde + NADPH + H+ Homo sapiens
-
glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+ Sus scrofa
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Homo sapiens
-
glycerol + NADP+
-
r
L-glyceraldehyde + NADPH Sus scrofa
-
glycerol + NADP+
-
r

Organism

Organism UniProt Comment Textmining
Equus sp.
-
horse
-
Homo sapiens
-
human
-
Pecten maximus
-
mollusc
-
Sus scrofa
-
pig
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
brain
-
Sus scrofa
-
heart
-
Homo sapiens
-
heart
-
Sus scrofa
-
kidney
-
Homo sapiens
-
kidney
-
Sus scrofa
-
lens
-
Homo sapiens
-
lens
-
Sus scrofa
-
liver
-
Homo sapiens
-
liver
-
Sus scrofa
-
liver
-
Equus sp.
-
muscle
-
Sus scrofa
-
muscle
-
Pecten maximus
-
muscle skeletal muscle Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
14.3
-
pure aldehyde reductase Homo sapiens
15.7
-
-
Homo sapiens

Storage Stability

Storage Stability Organism
4°C stable for several months but loss of activity with a concomitant enzyme precipitation occurs upon freezing and thawing Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(+)-camphorquinone + NADPH
-
Homo sapiens ? + NADP+
-
?
(+)-camphorquinone + NADPH
-
Sus scrofa ? + NADP+
-
?
4-hydroxy-3-methoxybenzyl alcohol + NADP+
-
Homo sapiens 4-hydroxy-3-methoxybenzaldehyde + NADPH
-
r
benzaldehyde + NADPH
-
Homo sapiens benzyl alcohol + NADP+
-
r
benzaldehyde + NADPH
-
Sus scrofa benzyl alcohol + NADP+
-
r
camphorquinone + NADPH + H+
-
Homo sapiens 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol + NADP+
-
?
D-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
D-glyceraldehyde + NADPH + H+
-
Sus scrofa glycerol + NADP+
-
r
D-lactaldehyde + NADPH + H+
-
Homo sapiens propane-1,2-diol + NADP+
-
r
D-lactaldehyde + NADPH + H+
-
Sus scrofa propane-1,2-diol + NADP+
-
r
DL-glyceraldehyde + NADPH + H+
-
Homo sapiens glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Homo sapiens glycerol + NADP+
-
r
L-glyceraldehyde + NADPH
-
Sus scrofa glycerol + NADP+
-
r
m-nitrobenzaldehyde + NADPH
-
Homo sapiens m-nitrobenzylalcohol + NADP+
-
r
m-nitrobenzaldehyde + NADPH
-
Sus scrofa m-nitrobenzylalcohol + NADP+
-
r
methylglyoxal + NADPH
-
Homo sapiens ? + NADP+
-
r
methylglyoxal + NADPH
-
Sus scrofa ? + NADP+
-
r
additional information
-
Sus scrofa ?
-
?
additional information no enzymatic activity in the presence of NADPH with acetaldehyde, pyridoxal, pyridoxal phosphate, glyceraldehyde phosphate, glucose or fructose, no activity in the reverse reaction with ethanol, cyclohexanol, phenylpropyl alcohol and glycerol phosphate Homo sapiens ?
-
?
n-butyraldehyde + NADPH
-
Homo sapiens n-butanol + NADP+
-
r
n-butyraldehyde + NADPH
-
Sus scrofa n-butanol + NADP+
-
r
p-carboxybenzaldehyde + NADPH
-
Homo sapiens p-carboxybenzyl alcohol + NADP+
-
r
p-carboxybenzaldehyde + NADPH
-
Sus scrofa p-carboxybenzyl alcohol + NADP+
-
r
p-chlorobenzaldehyde + NADPH + H+
-
Homo sapiens p-chlorobenzyl alcohol + NADP+
-
r
p-chlorobenzaldehyde + NADPH + H+
-
Sus scrofa p-chlorobenzyl alcohol + NADP+
-
r
p-nitrobenzaldehyde + NADPH cofactor NADPH Homo sapiens p-nitrobenzylalcohol + NADP+
-
r
p-nitrobenzaldehyde + NADPH cofactor NADPH Sus scrofa p-nitrobenzylalcohol + NADP+
-
r
phenylethanediol + NADP+
-
Homo sapiens ?
-
r
phenylethanol + NADP+
-
Homo sapiens phenylacetaldehyde + NADPH + H+
-
r
propane-1,2-diol + NADP+
-
Homo sapiens lactaldehyde + NADPH
-
r
propane-1,2-diol + NADP+
-
Sus scrofa lactaldehyde + NADPH
-
r
propionaldehyde + NADPH
-
Homo sapiens propanol + NADP+
-
r

Subunits

Subunits Comment Organism
monomer
-
Sus scrofa
monomer
-
Pecten maximus
monomer 1 * 39400, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
liver alcohol dehydrogenase
-
Equus sp.
Octopine dehydrogenase
-
Pecten maximus

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0283
-
glycerol
-
Homo sapiens
0.0283
-
Phenylethanol
-
Homo sapiens
0.0433
-
Propane-1,2-diol
-
Homo sapiens
0.0733
-
benzylalcohol
-
Homo sapiens
0.08
-
phenylethanediol
-
Homo sapiens
0.148
-
4-Hydroxy-3-methoxybenzyl alcohol
-
Homo sapiens
9.5
-
p-nitrobenzaldehyde
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.6
-
reduction of p-nitrobenzaldehyde in presence of NADPH Homo sapiens
9 9.5 oxidation of benzyl alcohol in presence of NADP+ Homo sapiens