Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | equimolar to substrate, 15% activation | Homo sapiens | |
Oxytocin | equimolar to substrate, 19% activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17beta-estradiol | equimolar to substrate inhibits 49% of enzyme activity | Homo sapiens | |
aspirin | equimolar to substrate inhibits 65% of enzyme activity | Homo sapiens | |
cortisol | equimolar to substrate inhibits 55% of enzyme activity | Homo sapiens | |
indomethacin | equimolar to substrate inhibits 81% of enzyme activity | Homo sapiens | |
lonazolac | equimolar to substrate inhibits 78% of enzyme activity | Homo sapiens | |
progesterone | equimolar to substrate inhibits 69% of enzyme activity | Homo sapiens | |
vitamin D3 | equimolar to substrate inhibits 38% of enzyme activity | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0016 | - |
NADPH | - |
Homo sapiens | |
0.08 | - |
prostaglandin E2 | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
33000 | - |
gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ | Homo sapiens | might be an important factor in the cascade of events leading to uterine contractions and parturition | (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
decidua parietalis | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00038 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ | - |
Homo sapiens | (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ | - |
r | |
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ | might be an important factor in the cascade of events leading to uterine contractions and parturition | Homo sapiens | (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.3 | - |
forward reaction | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |