Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens | |
Oxytocin | - |
Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
17beta-estradiol | - |
Homo sapiens | |
cortisol | - |
Homo sapiens | |
Fentiazac | non competitive | Homo sapiens | |
indomethacin | non competitive | Homo sapiens | |
progesterone | non competitive | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0016 | - |
NADPH | - |
Homo sapiens | |
0.092 | - |
prostaglandin E2 | - |
Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
29000 | - |
gel filtration | Homo sapiens |
31000 | - |
alpha, 1 * 31000, SDS-PAGE | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ | Homo sapiens | might be an important factor in the cascade of events leading to uterine contractions and parturition | (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
decidua parietalis | uterine | Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.00052 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ | - |
Homo sapiens | (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ | - |
? | |
(5Z,13E)-(15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ | might be an important factor in the cascade of events leading to uterine contractions and parturition | Homo sapiens | (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH + H+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | alpha, 1 * 31000, SDS-PAGE | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.45 | - |
Fentiazac | non competitive | Homo sapiens | |
0.85 | - |
indomethacin | non competitive | Homo sapiens | |
1.5 | - |
progesterone | non competitive | Homo sapiens |