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Literature summary for 1.1.1.188 extracted from

  • Phillips, R.J.; Al-Zamil, H.; Hunt, L.P.; Fortier, M.A.; Lopez Bernal, A.
    Genes for prostaglandin synthesis, transport and inactivation are differentially expressed in human uterine tissues, and the prostaglandin F synthase AKR1B1 is induced in myometrial cells by inflammatory cytokines (2011), Mol. Hum. Reprod., 17, 1-13.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
amnion expression of genes for PGE2 synthesis, with low levels of prostaglandin transporters and dehydrogenase Homo sapiens
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choriodecidua production of PGE2, PGF2 and PGD2 and high prostaglandin turnover Homo sapiens
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myometrium in pregnant myometrium, PGI2, PGD2 and PGF2 synthases are highly expressed while prostaglandin dehydrogenase is underexpressed. Myometrium from non-pregnant women has lower levels of prostaglandin synthases and higher levels of prostaglandin dehydrogenase than pregnant myometrium Homo sapiens
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placenta the prostaglandin synthase expression profile favours production of PGD2, PGE2 and PGF2, with high levels of prostaglandin transporters and catabolic prostaglandin dehydrogenase suggesting rapid prostaglandin turnover Homo sapiens
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uterus uterine tissues at delivery Homo sapiens
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Synonyms

Synonyms Comment Organism
AKR1B1
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Homo sapiens

Expression

Organism Comment Expression
Homo sapiens in cultured myometrial cells there is a dose-dependent stimulatory effect of interleukin 1beta and tumor necrosis factor alpha on PTGS2, PTGES and AKR1B1, i.e.PGF synthase expression up