Literature summary for 1.1.1.184 extracted from

Ramsden, D.; Smith, D.; Arenas, R.; Frederick, K.; Cerny, M.A.
Identification and characterization of a selective human carbonyl reductase 1 substrate (2018), Drug Metab. Dispos., 46, 1434-1440 .

Search for more literature for 1.1.1.184

Inhibitors

Inhibitors	Comment	Organism	Structure
Disulfiram	43.5% inhibition at 0.1 mM	Homo sapiens
Ethacrynic acid	34.4% inhibition at 0.1 mM	Homo sapiens
menadione	32.6% inhibition at 0.01 mM, 95.7% inhibition at 0.1 mM	Homo sapiens
quercetin	56.4% inhibition at 0.01 mM, 81.6% inhibition at 0.1 mM	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P16152	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
6-(4-acetyl-5-fluoropyridin-3-yl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide + NADPH + H+	selective substrate of human carbonyl reductase 1	Homo sapiens	6-[5-fluoro-4-[(1R)-1-hydroxyethyl]pyridin-3-yl]-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
carbonyl reductase 1	-	Homo sapiens
CBR1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)