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Literature summary for 1.1.1.184 extracted from

  • Zhang, R.; Wang, L.; Xu, Y.; Liang, H.; Zhou, X.; Jiang, J.; Li, Y.; Xiao, R.; Ni, Y.
    In situ expression of (R)-carbonyl reductase rebalancing an asymmetric pathway improves stereoconversion efficiency of racemic mixture to (S)-phenyl-1,2-ethanediol in Candida parapsilosis CCTCC M203011 (2016), Microb. Cell Fact., 15, 143.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
synthesis in situ expression in Candida leads to over fourfold higher activity for conversion of racemic (R,S)-1-phenyl-1,2-ethanediol to 2-hydroxyacetophenone, while maintaining the activity for catalyzing 2-hydroxyacetophenone to (S)-1-phenyl-1,2-ethanediol. A recombinant Candida parapsilosis converts racemic (R,S)-1-phenyl-1,2-ethanediol to its (S)-isomer with an optical purity of 98.8% and a yield of 48.4%. The biotransformation duration is reduced from 48 to 13 h Candida parapsilosis CCTCC M203011

Cloned(Commentary)

Cloned (Comment) Organism
-
Candida parapsilosis CCTCC M203011

Organism

Organism UniProt Comment Textmining
Candida parapsilosis CCTCC M203011 A1X808
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-1-phenyl-1,2-ethanediol + NADH + H+
-
Candida parapsilosis CCTCC M203011 2-hydroxyacetophenone + NAD+
-
r
hydroxyacetophenone + NAD+
-
Candida parapsilosis CCTCC M203011 (R)-1-phenyl-1,2-ethanediol + NADH + H+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
oxidation of (R)-1-phenyl-1,2-ethanediol Candida parapsilosis CCTCC M203011
35
-
reduction of hydroxyacetophenone Candida parapsilosis CCTCC M203011

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5
-
oxidation of (R)-1-phenyl-1,2-ethanediol Candida parapsilosis CCTCC M203011
6.5
-
reduction of hydroxyacetophenone Candida parapsilosis CCTCC M203011