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Literature summary for 1.1.1.184 extracted from

  • Shimada, H.; Tanigawa, T.; Matayoshi, K.; Katakura, K.; Babazono, K.; Takayama, H.; Murahashi, T.; Akita, H.; Higuchi, T.; Eto, M.; Imamura, Y.
    Comparative inhibition of tetrameric carbonyl reductase activity in pig heart cytosol by alkyl 4-pyridyl ketones (2014), J. Enzyme Inhib. Med. Chem., 29, 397-400.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
4-hexanoylpyridine competitive Sus scrofa
additional information the inhibitory potencies of alkyl 4-pyridyl ketones increases with an increase in the number up to five carbon atoms in the alkyl group, and 4-hexanoylpyridine is the most potent inhibitor of the enzyme activity. The inhibitory potencies of 4-heptanoylpyridine and 4-octanoylpyridine are lower than that of 4-hexanoylpyridine Sus scrofa

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Sus scrofa 5829
-

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-benzoylpyridine + NADPH + H+
-
Sus scrofa (S)-phenyl(pyridin-4-yl)methanol + NADP+
-
?

Synonyms

Synonyms Comment Organism
tetrameric carbonyl reductase
-
Sus scrofa