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Literature summary for 1.1.1.184 extracted from

  • Zhu, D.; Ankati, H.; Mukherjee, C.; Yang, Y.; Biehl, E.R.; Hua, L.
    Asymmetric reduction of beta-ketonitriles with a recombinant carbonyl reductase and enzymatic transformation to optically pure beta-hydroxy carboxylic acids (2007), Org. Lett., 9, 2561-2563.
    View publication on PubMed

Application

Application Comment Organism
synthesis synthesis of (R)-beta-hydroxynitriles with good optical purity by use of recombinant carbonyl reductase and further conversion to (R)-beta-hydroxy carboxylic acids via a nitrilase-catalyzed hydrolysis Starmerella magnoliae

Organism

Organism UniProt Comment Textmining
Starmerella magnoliae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-oxo-3-(2,4-difluorophenyl)propanenitrile + NADPH
-
Starmerella magnoliae (R)-3-hydroxy-3-(2,4-difluorophenyl)propanenitrile + NADP+ 92% yield, 98% enantiomeric excess ?
3-oxo-3-(3-methoxyphenyl)propanenitrile + NADPH
-
Starmerella magnoliae (R)-3-hydroxy-3-(3-methoxyphenyl)propanenitrile + NADP+ 89% yield, 97% enantiomeric excess ?
3-oxo-3-(3-nitrophenyl)propanenitrile + NADPH
-
Starmerella magnoliae (R)-3-hydroxy-3-(3-nitrophenyl)propanenitrile + NADP+ 87% yield, 99% enantiomeric excess ?
3-oxo-3-(4-bromophenyl)propanenitrile + NADPH
-
Starmerella magnoliae (R)-3-hydroxy-3-(4-bromophenyl)propanenitrile + NADP+ 88% yield, 99% enantiomeric excess ?
3-oxo-3-(4-chlorophenyl)propanenitrile + NADPH
-
Starmerella magnoliae (R)-3-hydroxy-3-(4-chlorophenyl)propanenitrile + NADP+ 90% yield, 99% enantiomeric excess ?
3-oxo-3-(4-cyanophenyl)propanenitrile + NADPH
-
Starmerella magnoliae (R)-3-hydroxy-3-(4-cyanophenyl)propanenitrile + NADP+ 90% yield, 99% enantiomeric excess ?
3-oxo-3-(4-fluorophenyl)propanenitrile + NADPH
-
Starmerella magnoliae (R)-3-hydroxy-3-(4-fluorophenyl)propanenitrile + NADP+ 90% yield, 99% enantiomeric excess ?
3-oxo-3-(4-methylphenyl)propanenitrile + NADPH
-
Starmerella magnoliae (R)-3-hydroxy-3-(4-methylphenyl)propanenitrile + NADP+ 90% yield, 98% enantiomeric excess ?
3-oxo-3-(4-nitrophenyl)propanenitrile + NADPH
-
Starmerella magnoliae (R)-3-hydroxy-3-(4-nitrophenyl)propanenitrile + NADP+ 86% yield, 99% enantiomeric excess ?
3-oxo-3-phenylpropanenitrile + NADPH
-
Starmerella magnoliae (R)-3-hydroxy-3-phenylpropanenitrile + NADP+ 85% yield, 98% enantiomeric excess ?