Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | CR expression is upregulated in brains suffering from Alzheimers disease | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
from brain | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | gene sniffer mutants are highly sensitive to hyperoxia-induced oxidative stress, mutations in the gene lead to a reduced life span, age-related neurodegeneration, and motoric dysfunctions that deteriorate with age, analysis of the central nervous system in sniffer mutants reveals signifcant cortex and neutrophil vacuolization and apoptosis in the brain, overexpression confers neuronal protection against oxygen-induced apoptosis, increases resistance of flies to experimental normobaric hyperoxia, and improves general locomotor fitness, overview | Drosophila melanogaster |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-oxonon-2-enal + NADPH + H+ | Homo sapiens | metabolic inactivation of the lipid peroxidation product, pathway overview | 1-hydroxynon-2-en-4-one + NADP+ | - |
? | |
4-oxonon-2-enal + NADPH + H+ | Homo sapiens | metabolic inactivation of the lipid peroxidation product, pathway overview | 4-hydroxynon-2-enal + NADP+ | - |
? | |
4-oxonon-2-enal + NADPH + H+ | Homo sapiens | metabolic inactivation of the lipid peroxidation product, pathway overview | 4-oxononanal + NADP+ | - |
? | |
glutathione-4-oxonon-2-enal + NADPH + H+ | Homo sapiens | metabolic inactivation of the lipid peroxidation product, pathway overview | glutathione-4-hydroxynon-2-enal + NADP+ | - |
? | |
additional information | Drosophila melanogaster | sniffer prevents age-dependent and oxidative stress-induced neurodegeneration in Drosophila melanogaster, formation of 4-hydroxyalkenals due to lipoprotein oxidation, and is shown to drive macrophage uptake and sub-intimal accumulation of oxidized lipids and lesion progression | ? | - |
? | |
additional information | Homo sapiens | the enzyme is responsible for detoxifcation of reactive aldehydes, CR has a potential physiological role for neuroprotection in humans and represents a signifcant pathway for the detoxifcation of reactive aldehydes derived from lipid peroxidation, CR is essential for neuronal cell survival and to confer protection against oxidative stress-induced brain degeneration, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | - |
gene sniffer | - |
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-oxonon-2-enal + NADPH + H+ | - |
Homo sapiens | 1-hydroxynon-2-en-4-one + NADP+ | - |
? | |
4-oxonon-2-enal + NADPH + H+ | metabolic inactivation of the lipid peroxidation product, pathway overview | Homo sapiens | 1-hydroxynon-2-en-4-one + NADP+ | - |
? | |
4-oxonon-2-enal + NADPH + H+ | - |
Homo sapiens | 4-hydroxynon-2-enal + NADP+ | - |
? | |
4-oxonon-2-enal + NADPH + H+ | metabolic inactivation of the lipid peroxidation product, pathway overview | Homo sapiens | 4-hydroxynon-2-enal + NADP+ | - |
? | |
4-oxonon-2-enal + NADPH + H+ | - |
Homo sapiens | 4-oxononanal + NADP+ | - |
? | |
4-oxonon-2-enal + NADPH + H+ | metabolic inactivation of the lipid peroxidation product, pathway overview | Homo sapiens | 4-oxononanal + NADP+ | - |
? | |
glutathione-4-oxonon-2-enal + NADPH + H+ | - |
Homo sapiens | glutathione-4-hydroxynon-2-enal + NADP+ | - |
? | |
glutathione-4-oxonon-2-enal + NADPH + H+ | metabolic inactivation of the lipid peroxidation product, pathway overview | Homo sapiens | glutathione-4-hydroxynon-2-enal + NADP+ | - |
? | |
additional information | sniffer prevents age-dependent and oxidative stress-induced neurodegeneration in Drosophila melanogaster, formation of 4-hydroxyalkenals due to lipoprotein oxidation, and is shown to drive macrophage uptake and sub-intimal accumulation of oxidized lipids and lesion progression | Drosophila melanogaster | ? | - |
? | |
additional information | the enzyme is responsible for detoxifcation of reactive aldehydes, CR has a potential physiological role for neuroprotection in humans and represents a signifcant pathway for the detoxifcation of reactive aldehydes derived from lipid peroxidation, CR is essential for neuronal cell survival and to confer protection against oxidative stress-induced brain degeneration, overview | Homo sapiens | ? | - |
? | |
additional information | the enzyme is active with steroids and prostaglandins | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carbonyl reductase | - |
Drosophila melanogaster |
carbonyl reductase | - |
Homo sapiens |
CR | - |
Drosophila melanogaster |
CR | - |
Homo sapiens |
More | the enzyme belongs to the short-chain dehydrogenase/reductase family | Drosophila melanogaster |
More | the enzyme belongs to the short-chain dehydrogenase/reductase family | Homo sapiens |
secondary-alcohol: NADP+-oxidoreductase | - |
Homo sapiens |
sniffer | - |
Drosophila melanogaster |