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Literature summary for 1.1.1.184 extracted from

  • Maser, E.
    Neuroprotective role for carbonyl reductase? (2006), Biochem. Biophys. Res. Commun., 340, 1019-1022.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information CR expression is upregulated in brains suffering from Alzheimer’s disease Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
from brain Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information gene sniffer mutants are highly sensitive to hyperoxia-induced oxidative stress, mutations in the gene lead to a reduced life span, age-related neurodegeneration, and motoric dysfunctions that deteriorate with age, analysis of the central nervous system in sniffer mutants reveals signifcant cortex and neutrophil vacuolization and apoptosis in the brain, overexpression confers neuronal protection against oxygen-induced apoptosis, increases resistance of flies to experimental normobaric hyperoxia, and improves general locomotor fitness, overview Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-oxonon-2-enal + NADPH + H+ Homo sapiens metabolic inactivation of the lipid peroxidation product, pathway overview 1-hydroxynon-2-en-4-one + NADP+
-
?
4-oxonon-2-enal + NADPH + H+ Homo sapiens metabolic inactivation of the lipid peroxidation product, pathway overview 4-hydroxynon-2-enal + NADP+
-
?
4-oxonon-2-enal + NADPH + H+ Homo sapiens metabolic inactivation of the lipid peroxidation product, pathway overview 4-oxononanal + NADP+
-
?
glutathione-4-oxonon-2-enal + NADPH + H+ Homo sapiens metabolic inactivation of the lipid peroxidation product, pathway overview glutathione-4-hydroxynon-2-enal + NADP+
-
?
additional information Drosophila melanogaster sniffer prevents age-dependent and oxidative stress-induced neurodegeneration in Drosophila melanogaster, formation of 4-hydroxyalkenals due to lipoprotein oxidation, and is shown to drive macrophage uptake and sub-intimal accumulation of oxidized lipids and lesion progression ?
-
?
additional information Homo sapiens the enzyme is responsible for detoxifcation of reactive aldehydes, CR has a potential physiological role for neuroprotection in humans and represents a signifcant pathway for the detoxifcation of reactive aldehydes derived from lipid peroxidation, CR is essential for neuronal cell survival and to confer protection against oxidative stress-induced brain degeneration, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
-
gene sniffer
-
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-oxonon-2-enal + NADPH + H+
-
Homo sapiens 1-hydroxynon-2-en-4-one + NADP+
-
?
4-oxonon-2-enal + NADPH + H+ metabolic inactivation of the lipid peroxidation product, pathway overview Homo sapiens 1-hydroxynon-2-en-4-one + NADP+
-
?
4-oxonon-2-enal + NADPH + H+
-
Homo sapiens 4-hydroxynon-2-enal + NADP+
-
?
4-oxonon-2-enal + NADPH + H+ metabolic inactivation of the lipid peroxidation product, pathway overview Homo sapiens 4-hydroxynon-2-enal + NADP+
-
?
4-oxonon-2-enal + NADPH + H+
-
Homo sapiens 4-oxononanal + NADP+
-
?
4-oxonon-2-enal + NADPH + H+ metabolic inactivation of the lipid peroxidation product, pathway overview Homo sapiens 4-oxononanal + NADP+
-
?
glutathione-4-oxonon-2-enal + NADPH + H+
-
Homo sapiens glutathione-4-hydroxynon-2-enal + NADP+
-
?
glutathione-4-oxonon-2-enal + NADPH + H+ metabolic inactivation of the lipid peroxidation product, pathway overview Homo sapiens glutathione-4-hydroxynon-2-enal + NADP+
-
?
additional information sniffer prevents age-dependent and oxidative stress-induced neurodegeneration in Drosophila melanogaster, formation of 4-hydroxyalkenals due to lipoprotein oxidation, and is shown to drive macrophage uptake and sub-intimal accumulation of oxidized lipids and lesion progression Drosophila melanogaster ?
-
?
additional information the enzyme is responsible for detoxifcation of reactive aldehydes, CR has a potential physiological role for neuroprotection in humans and represents a signifcant pathway for the detoxifcation of reactive aldehydes derived from lipid peroxidation, CR is essential for neuronal cell survival and to confer protection against oxidative stress-induced brain degeneration, overview Homo sapiens ?
-
?
additional information the enzyme is active with steroids and prostaglandins Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
carbonyl reductase
-
Drosophila melanogaster
carbonyl reductase
-
Homo sapiens
CR
-
Drosophila melanogaster
CR
-
Homo sapiens
More the enzyme belongs to the short-chain dehydrogenase/reductase family Drosophila melanogaster
More the enzyme belongs to the short-chain dehydrogenase/reductase family Homo sapiens
secondary-alcohol: NADP+-oxidoreductase
-
Homo sapiens
sniffer
-
Drosophila melanogaster