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Literature summary for 1.1.1.178 extracted from

  • Luo, M.J.; Mao, L.F.; Schulz, H.
    Short-chain 3-hydroxy-2-methylacyl-CoA dehydrogenase from rat liver: purification and characterization of a novel enzyme of isoleucine metabolism (1995), Arch. Biochem. Biophys., 321, 214-220.
    View publication on PubMed
Search for more literature for 1.1.1.178

Localization

Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
 2 * 28000, SDS-PAGE Rattus norvegicus
66000
-
 gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-methyl-3-hydroxybutyryl-CoA + NAD+ Rattus norvegicus
-
 2-methylacetoacetyl-CoA + NADH
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Sprague-Dawley rats
-

Purification (Commentary)

Purification (Comment) Organism
6-step procedure with yield of only 6% Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-methyl-3-hydroxybutyryl-CoA + NAD+
-
 Rattus norvegicus 2-methylacetoacetyl-CoA + NADH
-
 ?
3-hydroxybutyryl-CoA + NAD+
-
 Rattus norvegicus acetoacetyl-CoA + NADH
-
 ?

Subunits

Subunits Comment Organism
dimer 2 * 28000, SDS-PAGE Rattus norvegicus

Synonyms

Synonyms Comment Organism
short-chain L-3-hydroxy-2-methylacyl-CoA dehydrogenase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Rattus norvegicus