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Literature summary for 1.1.1.170 extracted from

  • Caldas, H.; Herman, G.E.
    NSDHL, an enzyme involved in cholesterol biosynthesis, traffics through the Golgi and accumulates on ER membranes and on the surface of lipid droplets (2003), Hum. Mol. Genet., 12, 2981-91.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
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Homo sapiens 5783
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lipid droplet surface of Homo sapiens 5811
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Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4alpha-carboxy-4beta-methyl-5alpha-cholesta-8-en-3beta-ol + NADP+ enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis Homo sapiens 4alpha-methyl-5alpha-cholesta-8-en-3-one + NADPH + CO2
-
?
4alpha-carboxy-5alpha-cholesta-8-en-3beta-ol + NADP+ enzyme is involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis Homo sapiens 5alpha-cholesta-8-en-3-one + CO2 + NADPH
-
?

Synonyms

Synonyms Comment Organism
C-3 sterol dehydrogenase(C-4 decarboxylase)
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Homo sapiens
NSDHL
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Homo sapiens

General Information

General Information Comment Organism
malfunction mutations in NSDHL gene are associated with human CHILD syndrome, congenital hemidysplasia with ichthyosiform nevus and limb defects Homo sapiens