Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2'-phospho-ADP-ribose | competitive | Escherichia coli | |
2'-phospho-AMP | competitive | Escherichia coli | |
ADP | competitive | Escherichia coli | |
AMP | competitive | Escherichia coli | |
ATP | noncompetitive | Escherichia coli | |
additional information | protein-ligand interaction determination and analysis | Escherichia coli | |
phosphate | competitive | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics and thermodynamics, overview | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ketopantoate + NADPH | Escherichia coli | the enzyme is involved in pantothenate, i.e. vitamin B5, biosynthesis, which is a precursor for CoA | pantoate + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
gene panE | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+ | protein-ligand interactions, overview | Escherichia coli |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ketopantoate + NADPH | - |
Escherichia coli | pantoate + NADP+ | - |
r | |
ketopantoate + NADPH | the enzyme is involved in pantothenate, i.e. vitamin B5, biosynthesis, which is a precursor for CoA | Escherichia coli | pantoate + NADP+ | - |
r |
Synonyms | Comment | Organism |
---|---|---|
ketopantoate reductase | - |
Escherichia coli |
KPR | - |
Escherichia coli |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Escherichia coli |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | NAD+/NADH are poor cofactors | Escherichia coli | |
NADP+ | protein-ligand interaction determination and analysis | Escherichia coli | |
NADPH | protein-ligand interaction determination and analysis | Escherichia coli |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
2'-phospho-ADP-ribose | pH 7.6 | Escherichia coli | |
0.24 | - |
2'-phospho-AMP | pH 7.6 | Escherichia coli | |
0.61 | - |
ATP | pH 7.6 | Escherichia coli | |
1.05 | - |
ADP | pH 7.6 | Escherichia coli | |
6.3 | - |
AMP | pH 7.6 | Escherichia coli | |
27 | - |
phosphate | pH 7.6 | Escherichia coli |