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Literature summary for 1.1.1.168 extracted from

  • Hata, H.; Shimizu, S.; Hattori, S.; Yamada, H.
    Ketopantoyl-lactone reductase from Candida parapsilosis: purification and characterization as a conjugated polyketone reductase (1989), Biochim. Biophys. Acta, 990, 175-181.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Candida parapsilosis

Inhibitors

Inhibitors Comment Organism Structure
3,4-Dihydroxy-3-cyclobutene-1,2-dione uncompetitive to isatin Candida parapsilosis
Al3+
-
Candida parapsilosis
Cd2+
-
Candida parapsilosis
Cu2+
-
Candida parapsilosis
Hg2+
-
Candida parapsilosis
iodoacetate
-
Candida parapsilosis
ketopantoyl lactone competitive to isatin Candida parapsilosis
p-chloromercuribenzoate
-
Candida parapsilosis
Polyketones cyclohexenediol-1,2,3,4-tetraone; e.g. parabanic acid Candida parapsilosis
quercetin
-
Candida parapsilosis
Zn2+
-
Candida parapsilosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.014
-
isatin
-
Candida parapsilosis
0.016
-
5-methylisatin
-
Candida parapsilosis
0.085
-
1-methylisatin
-
Candida parapsilosis
0.333
-
ketopantoyl lactone
-
Candida parapsilosis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
39000
-
gel filtration Candida parapsilosis
41600
-
1 * 41600, SDS-PAGE Candida parapsilosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2-dehydropantoyl lactone + NADPH Candida parapsilosis
-
(R)-pantoyl lactone + NADP+
-
ir
2-dehydropantoyl lactone + NADPH Candida parapsilosis IFO 0708
-
(R)-pantoyl lactone + NADP+
-
ir

Organism

Organism UniProt Comment Textmining
Candida parapsilosis
-
IFO 0708
-

Purification (Commentary)

Purification (Comment) Organism
IFO 0708 Candida parapsilosis

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
173
-
ketopantoyl lactone Candida parapsilosis
251
-
isatin Candida parapsilosis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methylisatin + NADPH
-
Candida parapsilosis ?
-
?
2-dehydropantoyl lactone + NADPH
-
Candida parapsilosis (R)-pantoyl lactone + NADP+
-
ir
2-dehydropantoyl lactone + NADPH
-
Candida parapsilosis IFO 0708 (R)-pantoyl lactone + NADP+
-
ir
5-methylisatin + NADPH
-
Candida parapsilosis ?
-
?
camphorquinone + NADPH
-
Candida parapsilosis ?
-
?
camphorquinone + NADPH
-
Candida parapsilosis IFO 0708 ?
-
?
isatin + NADPH and its derivatives Candida parapsilosis ?
-
?
isatin + NADPH and its derivatives Candida parapsilosis IFO 0708 ?
-
?
additional information carbonyl reductase specifically catalyzing the reduction of conjugated polyketones Candida parapsilosis additional information
-
?
additional information carbonyl reductase specifically catalyzing the reduction of conjugated polyketones Candida parapsilosis IFO 0708 additional information
-
?
naphthoquinone + NADPH
-
Candida parapsilosis ?
-
?
naphthoquinone + NADPH
-
Candida parapsilosis IFO 0708 ?
-
?

Subunits

Subunits Comment Organism
monomer 1 * 41600, SDS-PAGE Candida parapsilosis

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Candida parapsilosis

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
40
-
pH 7.0, 10 min, 58% loss of activity Candida parapsilosis
60
-
pH 7.0, 10 min, 77% loss of activity Candida parapsilosis

pH Stability

pH Stability pH Stability Maximum Comment Organism
4
-
30°C, 30 min, 33% loss of activity Candida parapsilosis
6 10
-
Candida parapsilosis