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Literature summary for 1.1.1.153 extracted from

  • Kim, K.; Kim, H.; Yim, J.
    Functional analysis of sepiapterin reductase in Drosophila melanogaster (2015), Pteridines, 26, 63-68.
No PubMed abstract available

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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Synonyms

Synonyms Comment Organism
sepiapterin reductase
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Drosophila melanogaster

General Information

General Information Comment Organism
malfunction tetrahydrobiopterin deficiencies are implicated in neuronal disorders. Drosophile melanogastersloss-of-function enzyme mutants are resonsibel for hyposensitivityy to oxidative stress, enzyme activity and tetrahydrobiopterin levels in the mutants are significantly reduced compared to wild-type, while levels of phosphorylated Akt and total Akt protein are increased in the enzyme mutants Drosophila melanogaster
metabolism sepiapterin reductase is a key enzyme in the biosynthesis of tetrahydrobiopterin (BH4), an essential cofactor for the synthesis of important biogenic amines, including catecholamines and serotonin Drosophila melanogaster
physiological function sepiapterin reductase plays an important role in the Akt pathway Drosophila melanogaster