Cloned (Comment) | Organism |
---|---|
chromosomal location 2p14-2p12, RT-PCR expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a single nucleotide polymorphism around the SPR gene is involved in development of Parkonson's disease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH | Homo sapiens | - |
tetrahydrobiopterin + NADP+ | the cofactor for aromatic amino acid hydrolases in the biosynthesis of aromatc amino acids and dopamine | r | |
additional information | Homo sapiens | the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis, sepiapterin reductase expression is increased in Parkinsons disease brain tissue | ? | - |
? | |
sepiapterin + NADPH + H+ | Homo sapiens | - |
7,8-dihydrobiopterin + NADP+ | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | sepiapterin reductase expression is increased in Parkinsons disease brain tissue | Homo sapiens | - |
cerebellum | post-mortem semi-quantitative expression analysis in brain of control individuals and Parkinson disease patients, SPR expression is increased in Parkinson patients, but not in the other genes involved in the tetrahydrobiopterin biosynthesis, overview | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH | - |
Homo sapiens | tetrahydrobiopterin + NADP+ | - |
r | |
6-pyruvoyl-5,6,7,8-tetrahydropterin + NADPH | - |
Homo sapiens | tetrahydrobiopterin + NADP+ | the cofactor for aromatic amino acid hydrolases in the biosynthesis of aromatc amino acids and dopamine | r | |
additional information | the enzyme catalyzes the final step in the tetrahydrobiopterin biosynthesis, sepiapterin reductase expression is increased in Parkinsons disease brain tissue | Homo sapiens | ? | - |
? | |
sepiapterin + NADPH + H+ | - |
Homo sapiens | 7,8-dihydrobiopterin + NADP+ | - |
r |