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Literature summary for 1.1.1.153 extracted from

  • Choi, Y.K.; Park, J.S.; Kong, J.S.; Morio, T.; Park, Y.S.
    D-threo-tetrahydrobiopterin is synthesized via 1-oxo-2-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum Ax2 (2005), FEBS Lett., 579, 3085-3089.
    View publication on PubMed
Search for more literature for 1.1.1.153

Protein Variants

Protein Variants Comment Organism
additional information construction of insertion mutants, the gene disruption leads to complete loss of enzyme activity Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+ Dictyostelium discoideum
-
 D-sepiapterin + NADPH
-
 ?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+ Dictyostelium discoideum AX2
-
 D-sepiapterin + NADPH
-
 ?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ Dictyostelium discoideum
-
 L-sepiapterin + NADPH
-
 ?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ Dictyostelium discoideum AX2
-
 L-sepiapterin + NADPH
-
 ?
6-pyruvoyl tetrahydropterin + NADPH + H+ Dictyostelium discoideum
-
 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 ?
additional information Dictyostelium discoideum D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2 ?
-
 ?
additional information Dictyostelium discoideum AX2 D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Dictyostelium discoideum
-
-
-
Dictyostelium discoideum AX2
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum D-sepiapterin + NADPH
-
 ?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum D-sepiapterin + NADPH i.e. 1'-oxo-2'-D-hydroxypropyl-dihydropterin ?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum AX2 D-sepiapterin + NADPH
-
 ?
1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum AX2 D-sepiapterin + NADPH i.e. 1'-oxo-2'-D-hydroxypropyl-dihydropterin ?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum L-sepiapterin + NADPH
-
 ?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum L-sepiapterin + NADPH i.e. 1'-oxo-2'-L-hydroxypropyl-dihydropterin ?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum AX2 L-sepiapterin + NADPH
-
 ?
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 Dictyostelium discoideum AX2 L-sepiapterin + NADPH i.e. 1'-oxo-2'-L-hydroxypropyl-dihydropterin ?
6-pyruvoyl tetrahydropterin + NADPH + H+
-
 Dictyostelium discoideum 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 ?
6-pyruvoyl tetrahydropterin + NADPH + H+ 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin is formed by an aldose reductase-like enzyme activity, not by SR Dictyostelium discoideum 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+
-
 ?
additional information D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2 Dictyostelium discoideum ?
-
 ?
additional information D-threo-tetrahydrobiopterin is synthesized via 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin in Dictyostelium discoideum strain Ax2 Dictyostelium discoideum AX2 ?
-
 ?

Synonyms

Synonyms Comment Organism
SR
-
 Dictyostelium discoideum

Cofactor

Cofactor Comment Organism Structure
NADP+
-
 Dictyostelium discoideum
NADPH
-
 Dictyostelium discoideum