Any feedback?
Literature summary for 1.1.1.153 extracted from
- Functional role of sepiapterin reductase in the biosynthesis of tetrahydropteridines in Dictyostelium discoideum Ax2 (2006), Biochim. Biophys. Acta, 1760, 877-882.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH | Dictyostelium discoideum | - |
tetrahydrodictyopterin + NADP+ | - |
? |  |
| 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH | Dictyostelium discoideum AX2 | - |
tetrahydrodictyopterin + NADP+ | - |
? | |
| 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH | Dictyostelium discoideum | - |
L-erythro-tetrahydrobiopterin + NADP+ | - |
? | |
| 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH | Dictyostelium discoideum AX2 | - |
L-erythro-tetrahydrobiopterin + NADP+ | - |
? | |
| 6-pyruvoyltetrahydropterin + NADPH | Dictyostelium discoideum | - |
1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ | no synthesis of the D-isomer | ? | |
| additional information | Dictyostelium discoideum | quantitative in vivo assay and product determination | ? | - |
? | |
| additional information | Dictyostelium discoideum AX2 | quantitative in vivo assay and product determination | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Dictyostelium discoideum | - |
- |
- |
| Dictyostelium discoideum AX2 | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | SR gene expression and activity in different developmental stages | Dictyostelium discoideum | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH | - |
Dictyostelium discoideum | tetrahydrodictyopterin + NADP+ | - |
? | |
| 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH | preferred substrate | Dictyostelium discoideum | tetrahydrodictyopterin + NADP+ | - |
? | |
| 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH | - |
Dictyostelium discoideum AX2 | tetrahydrodictyopterin + NADP+ | - |
? | |
| 1'-oxo-2'-D-hydroxypropyl-tetrahydropterin + NADPH | preferred substrate | Dictyostelium discoideum AX2 | tetrahydrodictyopterin + NADP+ | - |
? | |
| 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH | - |
Dictyostelium discoideum | L-erythro-tetrahydrobiopterin + NADP+ | - |
? | |
| 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADPH | - |
Dictyostelium discoideum AX2 | L-erythro-tetrahydrobiopterin + NADP+ | - |
? | |
| 6-pyruvoyltetrahydropterin + NADPH | - |
Dictyostelium discoideum | 1'-oxo-2'-L-hydroxypropyl-tetrahydropterin + NADP+ | no synthesis of the D-isomer | ? | |
| additional information | product determination | Dictyostelium discoideum | ? | - |
? | |
| additional information | quantitative in vivo assay and product determination | Dictyostelium discoideum | ? | - |
? | |
| additional information | product determination | Dictyostelium discoideum AX2 | ? | - |
? | |
| additional information | quantitative in vivo assay and product determination | Dictyostelium discoideum AX2 | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SR | - |
Dictyostelium discoideum |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 22 | - |
assay at | Dictyostelium discoideum |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | - |
assay at | Dictyostelium discoideum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Dictyostelium discoideum | |
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