Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH + H+ | Mus musculus | - |
corticosterone + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P50172 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
bone | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
11-dehydrocorticosterone + NADPH + H+ | - |
Mus musculus | corticosterone + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
11 beta-hydroxysteroid dehydrogenase type 1 | - |
Mus musculus |
11beta-HSD1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | global deletion of isoform 11beta-HSD1 drives an enhanced inflammatory phenotype, characterized by florid synovitis, joint destruction and systemic bone loss. This is associated with increased pannus invasion into subchondral bone, a marked polarisation towards pro-inflammatory M1 macrophages at sites of inflammation and increased osteoclast numbers | Mus musculus |
physiological function | isoform 11beta-HSD1 plays a fundamental role in the suppression of synovitis, joint destruction, and systemic bone loss | Mus musculus |