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Literature summary for 1.1.1.146 extracted from

  • Voisin, M.; de Medina, P.; Mallinger, A.; Dalenc, F.; Huc-Claustre, E.; et, al.
    Identification of a tumor-promoter cholesterol metabolite in human breast cancers acting through the glucocorticoid receptor (2017), Proc. Natl. Acad. Sci. USA, 114, E9346-E9355.
    View publication on PubMedView publication on EuropePMC
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Application

Application Comment Organism
medicine in breast cancer tissue, cholesterol epoxide hydrolase ChEH metabolizes cholesterol-5,6-epoxide into cholestane-3beta,5alpha,6beta-triol, which is transformed into the oncometabolite 6-oxo-cholestan-3beta,5alpha-diol by 11beta-hydroxysteroid-dehydrogenase 11betaHSD2. ChEH inhibition and 11betaHSD2 silencing inhibit 6-oxo-cholestan-3beta,5alpha-diol production and tumor growth. Patient breast cancer samples show significantly increased 6-oxocholestan-3beta,5alpha-diol levels and greater ChEH and 11betaHSD2 protein expression compared with normal tissues, and 11betaHSD2 and ChEH overexpression correlate with a higher risk of patient death Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
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 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P80365
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Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
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 Homo sapiens
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MDA-MB-231 cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cholestane-3beta,5alpha,6beta-triol + NAD(P)+
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 Homo sapiens 6-oxocholestan-3beta,5alpha-diol + NAD(P)H + H+
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 ?