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Literature summary for 1.1.1.146 extracted from

  • Morelli, V.; Polledri, E.; Mercadante, R.; Zhukouskaya, V.; Palmieri, S.; Beck-Peccoz, P.; Spada, A.; Fustinoni, S.; Chiodini, I.
    The activity of 11beta-hydroxysteroid dehydrogenase type 2 enzyme and cortisol secretion in patients with adrenal incidentalomas (2016), Endocrine, 53, 809-815.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme activity is inversely associated with urinary cortisol/cortisone levels and it is not associated with the subclinical hypercortisolism complications Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisol + NADP+ Homo sapiens
-
cortisone + NADPH + H+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisol + NADP+
-
Homo sapiens cortisone + NADPH + H+
-
?

Synonyms

Synonyms Comment Organism
11beta-hydroxysteroid dehydrogenase type 2
-
Homo sapiens
Hsd11B2
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens