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Literature summary for 1.1.1.146 extracted from

  • Itoi, S.; Terao, M.; Murota, H.; Katayama, I.
    11beta-Hydroxysteroid dehydrogenase 1 contributes to the pro-inflammatory response of keratinocytes (2013), Biochem. Biophys. Res. Commun., 440, 265-270.
    View publication on PubMed

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
32000
-
x * 32000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cortisone + NADPH + H+ Homo sapiens
-
cortisol + NADP+
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
keratinocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cortisone + NADPH + H+
-
Homo sapiens cortisol + NADP+
-
?

Subunits

Subunits Comment Organism
? x * 32000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
11beta-HSD1
-
Homo sapiens
11beta-hydroxysteroid dehydrogenase 1
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of isoform 11beta-HSD1 is induced by UV-B irradiation and in response to the pro-inflammatory cytokines, interleukin-1beta and tumor necrosis factor alpha up

General Information

General Information Comment Organism
physiological function isoform 11beta-HSD1 modulates a pro-inflammatory response in normal human epidermal keratinocytes by altering cortisol production Homo sapiens