Literature summary for 1.1.1.146 extracted from

Zhang, L.; Shen, Y.; Zhu, H.J.; Wang, F.; Leng, Y.; Liu, J.K.
Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11beta-hydroxysteroid dehydrogenases inhibitory activity (2009), J. Antibiot., 62, 239-242.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in HEK-293 cell	Mus musculus
expressed in HEK-293 cell	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
(2S)-5-(acetyloxy)-2-hydroxypentyl acetate	-	Homo sapiens
2-oxopentane-1,5-diyl diacetate	-	Homo sapiens
2-oxopentane-1,5-diyl diacetate	-	Mus musculus
5-hydroxy-4-oxopentyl acetate	-	Homo sapiens
5-hydroxy-4-oxopentyl acetate	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cortisone + NADPH + H+	-	Mus musculus	cortisol + NADP+	-	?
cortisone + NADPH + H+	-	Homo sapiens	cortisol + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
11beta-hydroxysteroid dehydrogenase 1	-	Mus musculus
11beta-hydroxysteroid dehydrogenase 1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Mus musculus
NADP+	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	IC50 = 0.0287 mg/ml, pH not specified in the publication, temperature not specified in the publication	Homo sapiens	2-oxopentane-1,5-diyl diacetate
additional information	-	IC50 = 0.0304 mg/ml, pH not specified in the publication, temperature not specified in the publication	Mus musculus	2-oxopentane-1,5-diyl diacetate
additional information	-	IC50 = 0.0474 mg/ml, pH not specified in the publication, temperature not specified in the publication	Homo sapiens	5-hydroxy-4-oxopentyl acetate
additional information	-	IC50 = 0.0623 mg/ml, pH not specified in the publication, temperature not specified in the publication	Homo sapiens	(2S)-5-(acetyloxy)-2-hydroxypentyl acetate
additional information	-	IC50 = 0.1492 mg/ml, pH not specified in the publication, temperature not specified in the publication	Mus musculus	5-hydroxy-4-oxopentyl acetate

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Release 2023.1 (January 2023)