Activating Compound | Comment | Organism | Structure |
---|---|---|---|
glucose | coexpression with hexose-6-phosphate dehydrogenase potentiates 11beta-HSD1 reductase activity at high glucose, this effect is significantly decreased at low glucose, with concomitantly increased 11beta-HSD1 dehydrogenase activity | Mus musculus | |
glucose | coexpression with hexose-6-phosphate dehydrogenase potentiates 11beta-HSD1 reductase activity at high glucose, this effect is significantly decreased at low glucose, with concomitantly increased 11beta-HSD1 dehydrogenase activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expressed in HEK-293 cells | Homo sapiens |
expressed in rat H4IIE hepatoma cells | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Mus musculus | - |
- |
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
3T3-L1 cell | - |
Mus musculus | - |
adipocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cortisol + NADP+ | - |
Mus musculus | cortisone + NADPH | - |
r | |
cortisol + NADP+ | - |
Homo sapiens | cortisone + NADPH | - |
r |
Synonyms | Comment | Organism |
---|---|---|
11beta-HSD1 | - |
Mus musculus |
11beta-HSD1 | - |
Homo sapiens |
11beta-hydroxysteroid dehydrogenase 1 | - |
Mus musculus |
11beta-hydroxysteroid dehydrogenase 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | 11beta-hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ | Mus musculus | |
NADP+ | 11beta-hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ | Homo sapiens | |
NADPH | 11beta-hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ | Mus musculus | |
NADPH | 11beta-hydroxysteroid dehydrogenase 1 reductase activity is dependent on a high ratio of NADPH/NADP+ | Homo sapiens |