Literature summary for 1.1.1.146 extracted from

Gumy, C.; Thurnbichler, C.; Aubry, E.M.; Balazs, Z.; Pfisterer, P.; Baumgartner, L.; Stuppner, H.; Odermatt, A.; Rollinger, J.M.
Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines (2009), Fitoterapia, 80, 200-205.

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Inhibitors

Inhibitors	Comment	Organism	Structure
glycyrrhetinic acid	11beta-HSD1 shows 21% residual activity at 0.01 mM, 11beta-HSD2 shows 16% residual activity at 0.01 mM	Homo sapiens
additional information	leaf extracts of Eriobotrya japonica preferentially inhibit 11beta-HSD1 over 11beta-HSD2, extracts of roasted but not native coffee beans preferentially inhibit 11beta-HSD1 over 11beta-HSD2	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
cortisol + NADP+	the reaction is catalysed by 11beta-HSD2	Homo sapiens	cortisone + NADPH	-	?
cortisone + NADPH + H+	reaction is catalysed by 11beta-HSD1	Homo sapiens	cortisol + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
11beta-HSD1	-	Homo sapiens
11beta-HSD2	-	Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1	-	Homo sapiens
11beta-hydroxysteroid dehydrogenase type 2	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADP+	-	Homo sapiens
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)