Literature summary for 1.1.1.146 extracted from

Swali, A.; Walker, E.A.; Lavery, G.G.; Tomlinson, J.W.; Stewart, P.M.
11beta-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets (2008), Diabetologia, 51, 2003-2011.

Search for more literature for 1.1.1.146

Inhibitors

Inhibitors	Comment	Organism	Structure
PF-877423	specific 11beta-HSD1 inhibitor	Homo sapiens
PF-877423	specific 11beta-HSD1 inhibitor	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreatic islet	11beta-HSD1 co-localises with glucagon in the periphery of pancreatic islets, but not with insulin or somatostatin	Mus musculus	-
pancreatic islet	11beta-HSD1 co-localises with glucagon in the periphery of pancreatic islets, but not with insulin or somatostatin	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
11-dehydrocorticosterone + NADPH	-	Mus musculus	corticosterone + NADP+	-	?
11-dehydrocorticosterone + NADPH	-	Homo sapiens	corticosterone + NADP+	-	?
cortisone + NADPH + H+	-	Mus musculus	cortisol + NADP+	-	?
cortisone + NADPH + H+	-	Homo sapiens	cortisol + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
11beta-HSD1	-	Mus musculus
11beta-HSD1	-	Homo sapiens
11beta-hydroxysteroid dehydrogenase type 1	-	Mus musculus
11beta-hydroxysteroid dehydrogenase type 1	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Mus musculus
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)