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Literature summary for 1.1.1.146 extracted from

  • Sunak, N.; Green, D.F.; Abeydeera, L.R.; Thurston, L.M.; Michael, A.E.
    Implication of cortisol and 11beta -hydroxysteroid dehydrogenase enzymes in the development of porcine (Sus scrofa domestica) ovarian follicles and cysts (2007), Reproduction, 133, 1149-1158.
    View publication on PubMed

Application

Application Comment Organism
medicine activation of cortisol by 11beta-hydroxysteroid dehydrogenase in granulosa cells increases with follicle development but is significantly decreased in ovarion cysts Sus scrofa
medicine changes in ovarian cortisol metabolism are accompanied by corresponding changes in the levels of paracrine inhibitors of 11beta-hydroxysteroid dehydrogenase within growing ovarian follicles and cysts Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
follicular fluid follicular fluid from small antral follicles inhibits the enzyme in kidney homogenates by 50%, follicular fluid from large antral follicles inhibits by 23%, cyst fluid inhibits by 59%. Net cortisol oxidation in granulosa cells decreases by 35-48% when treated with follicular fluid from large antral follicles, and by 45-75% when treated with cyst fluid Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Sus scrofa
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Source Tissue

Source Tissue Comment Organism Textmining
cyst ovarian cyst Sus scrofa
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granulosa cell cortisol oxidation increases threefold with antral follicle diameter, accompanied by threefold increase in 11beta-hydroxysteroid dehydrogenase activity. Neither intact cells nor homogenates display net 11-ketosteroid reductase activities. Intact granulosa cells from ovarian cysts exhibit significantly lower enzyme activities than cells from large antral follicles Sus scrofa
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kidney
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Rattus norvegicus
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ovarian follicle
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Sus scrofa
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