Application | Comment | Organism |
---|---|---|
medicine | activation of cortisol by 11beta-hydroxysteroid dehydrogenase in granulosa cells increases with follicle development but is significantly decreased in ovarion cysts | Sus scrofa |
medicine | changes in ovarian cortisol metabolism are accompanied by corresponding changes in the levels of paracrine inhibitors of 11beta-hydroxysteroid dehydrogenase within growing ovarian follicles and cysts | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
follicular fluid | follicular fluid from small antral follicles inhibits the enzyme in kidney homogenates by 50%, follicular fluid from large antral follicles inhibits by 23%, cyst fluid inhibits by 59%. Net cortisol oxidation in granulosa cells decreases by 35-48% when treated with follicular fluid from large antral follicles, and by 45-75% when treated with cyst fluid | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Sus scrofa | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
cyst | ovarian cyst | Sus scrofa | - |
granulosa cell | cortisol oxidation increases threefold with antral follicle diameter, accompanied by threefold increase in 11beta-hydroxysteroid dehydrogenase activity. Neither intact cells nor homogenates display net 11-ketosteroid reductase activities. Intact granulosa cells from ovarian cysts exhibit significantly lower enzyme activities than cells from large antral follicles | Sus scrofa | - |
kidney | - |
Rattus norvegicus | - |
ovarian follicle | - |
Sus scrofa | - |